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. 2017 Oct;15(10):635-640.

The effect of vitamin E and aspirin on the uterine artery blood flow in women with recurrent abortion: A single-blind randomized controlled trial

Elaheh Mesdaghinia  1 , Behnaz Mohammad-Ebrahimi  1 , Fatemeh Foroozanfard  1 , Hamid Reza Banafshe  2   3
Affiliations

The effect of vitamin E and aspirin on the uterine artery blood flow in women with recurrent abortion: A single-blind randomized controlled trial

Elaheh Mesdaghinia et al. Int J Reprod Biomed. 2017 Oct.

Abstract

Background: Recurrent spontaneous abortion has high incidence rate. The etiology is unknown in 30-40%. However high uterine artery resistance is accounted as one of the recurrent abortion reasons.

Objective: The objective of the current study was to determine the impacts of vitamin E and aspirin on the uterine artery blood flow in women having recurrent abortions due to impaired uterine blood flow.

Materials and methods: This randomized clinical trial was conducted on 99 women having uterine pulsatility index (PI) more than 2.5 and the history of more than two times abortions. The candidates were categorized into three groups; receiving aspirin, only vitamin E, and aspirin+vitamin E. After 2 months, uterine PIs were compared with each other.

Results: All drug regimens caused an enhancement in uterine perfusion with a significant decline in uterine artery PI value. The women receiving vitamin E in accompanied with aspirin had the least mean PI of the uterine artery (p<0.001). The total average PI score of the right and left uterine arteries in groups receiving vitamin E in accompanied with aspirin was lower than the two counterparts significantly (p<0.001).

Conclusion: Vitamin E, aspirin and especially their combination are effective in improving uterine artery blood flow in women with recurrent abortion due to impaired uterine blood flow. More well-designed studies are needed to find out whether the enhancement of uterine perfusion may lead to a better pregnancy outcome.

Keywords: Aspirin; Pulsatility index; Recurrent abortion; Vitamin E.

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Conflict of interest statement

The authors have no conflict of interest.

Figures

Figure 1
Figure 1
Consort flow chart of clinical trial
Figure 2
Figure 2
The mean uterine pulsatility index values before and after two months of therapy with aspirin (100mg/day), vitamin E (400mg/ day) and their combination. Data were expressed as mean ± SD. P-value of 0.05 was considered statistically significant.
See this image and copyright information in PMC

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