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Review
. 2017 Apr 11:8:29-37.
doi: 10.2147/PHMT.S100803. eCollection 2017.

Steroid-resistant nephrotic syndrome: past and current perspectives

Noureddin Nourbakhsh  1 , Robert H Mak  1
Affiliations
Review

Steroid-resistant nephrotic syndrome: past and current perspectives

Noureddin Nourbakhsh et al. Pediatric Health Med Ther. .

Abstract

Patients with steroid-resistant nephrotic syndrome (SRNS) represent a challenging subset of patients with nephrotic syndrome who often fail standard immunosuppression and have a higher likelihood of progressing to end-stage renal disease. Appropriate treatment of SRNS requires an adequate understanding of the historical treatment, renal histopathology, and genetics associated with the disease. The aim of this review is to present a comprehensive appraisal of the history, role of renal biopsy, genetics, and treatment of SRNS.

Keywords: focal segmental glomerulosclerosis; steroid-resistant nephrotic syndrome.

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Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Systematic approach to genetic testing in children with steroid-resistant nephrotic syndrome. Note: Adapted from Benoit G, Machuca E, Antignac C. Hereditary nephrotic syndrome: a systematic approach for genetic testing and a review of associated podocyte gene mutations. Pediatr Nephrol. 2010;25(9):1621–1632. Abbreviations: FSGS, focal segmental glomerulosclerosis; PLCE1, phospholipase C epsilon 1.
See this image and copyright information in PMC

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