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Review
. 2017 Dec 6:8:107-116.
doi: 10.2147/PHMT.S115528. eCollection 2017.

Current perspectives on the optimal management of infantile hemangioma

Peter Grzesik  1 , June K Wu  1
Affiliations
Review

Current perspectives on the optimal management of infantile hemangioma

Peter Grzesik et al. Pediatric Health Med Ther. .

Abstract

Infantile hemangiomas (IHs) are the most common benign tumor of infancy. As our understanding of their pathobiology has evolved, treatment has become more focused and tailored to specifically treat IH while minimizing adverse effects. Propranolol has gained FDA approval as the first medical therapy for a traditionally surgical disease. This review provides readers with an overview of IH, treatment modalities, and addresses specific considerations in IH disease management.

Keywords: complications of infantile hemangioma; infantile hemangioma; medical treatment indications; propranolol.

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Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
(A) A proliferating IH on the cheek of an infant. Note the ulceration in the center of the IH. (B) A proliferating IH is highly cellular with poorly defined vascular spaces (black arrowheads). Note: Magnification of image B, 40×; scale bar =50 µm. Abbreviation: IH, infantile hemangioma.
Figure 2
Figure 2
(A) An involuting IH on the arm of a toddler. Note the graying red color when compared to the proliferating IH. (B) Histology: involuting IHs have fewer cells and organized vascular tubular structures (black arrowheads). Note: Magnification of image B, 40×; scale bar =50 µm. Abbreviation: IH, infantile hemangioma.
Figure 3
Figure 3
Both proliferating (A) and involuting (B) IH endothelial cells express GLUT1 (green). Notes: Magnification, 40×; scale bars =50 µm. Right column indicates close-up views. Abbreviations: IH, infantile hemangioma; GLUT1, glucose transporter 1.
Figure 4
Figure 4
(A) Intraoperative photo demonstrating that IH can be easily separated from the surrounding soft tissue. Note facial monitoring devices in place. These can be used to assist during facial dissection. Course telangiectasia can be seen as well (arrowheads). (B) Feeding vessels to the IH need to be identified (black arrowhead) and isolated before dividing to minimize blood loss. Abbreviation: IH, infantile hemangioma.
See this image and copyright information in PMC

References

    1. Mulliken JB, Glowacki J. Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics. Plast Reconstr Surg. 1982;69(3):412–422. - PubMed
    1. Frieden IJ, Haggstrom AN, Drolet BA, et al. Infantile hemangiomas: current knowledge, future directions. Proceedings of a research workshop on infantile hemangiomas, April 7–9, 2005, Bethesda, Maryland, USA. Pediatr Dermatol. 2005;22(5):383–406. - PubMed
    1. Smith CJF, Friedlander SF, Guma M, Kavanaugh A, Chambers CD. Infantile hemangiomas: an updated review on risk factors, pathogenesis, and treatment. Birth Defects Res. 2017;109(11):809–815. - PMC - PubMed
    1. Mulliken JB, Fishman SJ, Burrows PE. Vascular anomalies. Curr Probl Surg. 2000;37(8):517–584. - PubMed
    1. Hemangioma Investigator Group. Haggstrom AN, Drolet BA, et al. Prospective study of infantile hemangiomas: demographic, prenatal, and perinatal characteristics. J Pediatr. 2007;150(3):291–294. - PubMed

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