Molecular, histological, and clinical phenotyping of diabetic nephropathy: valuable complementary information?
- PMID: 29389397
- DOI: 10.1016/j.kint.2017.10.026
Molecular, histological, and clinical phenotyping of diabetic nephropathy: valuable complementary information?
Abstract
The incidence and prevalence of diabetic kidney disease is increasing. Observational and interventional studies suggest that the pathophysiology varies between individuals and within a patient over time. There is a huge clinical need to describe the molecular processes that modulate diabetic kidney disease. "Omics" experiments combined with bioinformatical analysis tools might allow for profiling of patients on an individual or at least group level to improve prediction of prognosis and guide targeted therapy.
Copyright © 2017 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.
Comment on
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A molecular morphometric approach to diabetic kidney disease can link structure to function and outcome.Kidney Int. 2018 Feb;93(2):439-449. doi: 10.1016/j.kint.2017.08.013. Epub 2017 Oct 18. Kidney Int. 2018. PMID: 29054530 Free PMC article.
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