Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Feb 1;13(2):e0191804.
doi: 10.1371/journal.pone.0191804. eCollection 2018.

Dynamic re-immunization of off-treatment childhood cancer survivors: An implementation feasibility study

Jennifer H Han  1 , Kathryn M Harmoney  2 , Elif Dokmeci  3 , Jacqueline Torrez  4 , Cathy M Chavez  4 , Loretta Cordova de Ortega  1 , John F Kuttesch  4 , Martha Muller  5 , Stuart S Winter  6
Affiliations

Dynamic re-immunization of off-treatment childhood cancer survivors: An implementation feasibility study

Jennifer H Han et al. PLoS One. .

Abstract

There are no universally approved re-vaccination guidelines for non-transplant pediatric cancer survivors. We hypothesized that by utilizing a response-based re-vaccination schedule, we could tailor vaccine schedules in off-treatment cancer survivors. Pre-vaccination antibody levels were obtained in 7 patients at an average of 20 days after the end of treatment date. In those without protective antibody levels, we administered vaccines 3 months after completion of treatment. Revaccinating patients 3 months after the end of treatment date resulted in protective antibody levels for most vaccines. We showed, on a preliminary basis, that vaccinating non-transplanted pediatric cancer survivors can be dynamically implemented in children with recovering immune function.

PubMed Disclaimer

Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Similar articles

See all similar articles

Cited by

References

    1. Brodtman DH, Rosenthal DW, Redner A, Lanzkowsky P, Bonagura VR. Immunodeficiency in children with acute lymphoblastic leukemia after completion of modern aggressive chemotherapeutic regimens. J Pediatr. 2005;146(5):654–61. doi: 10.1016/j.jpeds.2004.12.043 . - DOI - PubMed
    1. Patel SR, Ortin M, Cohen BJ, Borrow R, Irving D, Sheldon J, et al. Revaccination of children after completion of standard chemotherapy for acute leukemia. Clin Infect Dis. 2007;44(5):635–42. doi: 10.1086/511636 . - DOI - PubMed
    1. Shetty AK, Winter MA. Immunization of children receiving immunosuppressive therapy for cancer or hematopoietic stem cell transplantation. Ochsner J. 2012;12(3):228–43. ; PubMed Central PMCID: PMCPMC3448245. - PMC - PubMed
    1. Ercan TE, Soycan LY, Apak H, Celkan T, Ozkan A, Akdenizli E, et al. Antibody titers and immune response to diphtheria-tetanus-pertussis and measles-mumps-rubella vaccination in children treated for acute lymphoblastic leukemia. J Pediatr Hematol Oncol. 2005;27(5):273–7. . - PubMed
    1. Lehrnbecher T, Schubert R, Allwinn R, Dogan K, Koehl U, Gruttner HP. Revaccination of children after completion of standard chemotherapy for acute lymphoblastic leukaemia: a pilot study comparing different schedules. Br J Haematol. 2011;152(6):754–7. doi: 10.1111/j.1365-2141.2010.08522.x . - DOI - PubMed