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. 2018 Feb 1;13(2):e0191804.
doi: 10.1371/journal.pone.0191804. eCollection 2018.

Dynamic re-immunization of off-treatment childhood cancer survivors: An implementation feasibility study

Jennifer H Han  1 , Kathryn M Harmoney  2 , Elif Dokmeci  3 , Jacqueline Torrez  4 , Cathy M Chavez  4 , Loretta Cordova de Ortega  1 , John F Kuttesch  4 , Martha Muller  5 , Stuart S Winter  6
Affiliations

Dynamic re-immunization of off-treatment childhood cancer survivors: An implementation feasibility study

Jennifer H Han et al. PLoS One. .

Abstract

There are no universally approved re-vaccination guidelines for non-transplant pediatric cancer survivors. We hypothesized that by utilizing a response-based re-vaccination schedule, we could tailor vaccine schedules in off-treatment cancer survivors. Pre-vaccination antibody levels were obtained in 7 patients at an average of 20 days after the end of treatment date. In those without protective antibody levels, we administered vaccines 3 months after completion of treatment. Revaccinating patients 3 months after the end of treatment date resulted in protective antibody levels for most vaccines. We showed, on a preliminary basis, that vaccinating non-transplanted pediatric cancer survivors can be dynamically implemented in children with recovering immune function.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

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