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Review
. 2017 Dec;96(51):e9212.
doi: 10.1097/MD.0000000000009212.

Three-week topical treatment with placenta-derived mesenchymal stem cells hydrogel in a patient with diabetic foot ulcer: A case report

Xiangxia Zeng  1 , Yunliang Tang, Kaixiang Hu, Wang Jiao, Liu Ying, Lingyan Zhu, Jianying Liu, Jixiong Xu
Affiliations
Review

Three-week topical treatment with placenta-derived mesenchymal stem cells hydrogel in a patient with diabetic foot ulcer: A case report

Xiangxia Zeng et al. Medicine (Baltimore). 2017 Dec.

Erratum in

Abstract

Rationale: Diabetic foot ulcer (DFU) is a chronic complication of diabetes characterized by continuity, repeatability, and nonhealing. In recent years, mesenchymal stem cells hydrogel complex has been a new emerging technique in the treatment of DFU. The placenta-derived mesenchymal stem cells (PDMSCs) hydrogel is multipotent, and can secrete growth factors, cytokines, and immunomodulatory substances which could accelerate wound healing.

Patient concerns: In this case report, we present a 57-year-old female with type 2 diabetes mellitus and a 20-day DFU.A wound bed located at the dorsalis pedis of the right foot, and conventional therapies had no effect on the foot.

Diagnoses: The patient was confirmed a diagnosis of type 2 DM with diabetic foot (Wagner classification III).

Interventions: To assess the efficacy and safety of PDMSCs hydrogel in wound repair and to improve the rate of wound healing, we administered PDMSCs hydrogel (cell number: 1 × 10/cells/cm) topically into the wound with the patient's permission.

Outcomes: The patient's foot ulcer was almost healed, and foot function in walking was well preserved. No complications were observed. No recurrence occurred in the subsequent 6 months.

Lessons: To the best of our knowledge, this is the first patient globally to receive PDMSCs hydrogel to treat DFU. The present case study suggests that PDMSCs hydrogel may provide a new approach to DFU treatment. Clinical Trial Registration-URL: http://www.chictr.org.cn/searchproj.aspx:chiCRT-ONC-16008732.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Nonhealing wound at the right dorsum pedis of a 57-year-old female with type 2 diabetes mellitus.
Figure 2
Figure 2
Right dorsum pedis wound 72 h after treatment with placenta-derived mesenchymal stem cells hydrogel, showing clearly decreased purulent secretions and wound size.
Figure 3
Figure 3
Wound almost healed 3 weeks after treatment with placenta-derived mesenchymal stem cells hydrogel.
See this image and copyright information in PMC

References

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