Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1986 Mar;17(3):281-6.
doi: 10.1093/jac/17.3.281.

Activity of ciprofloxacin against resistant clinical isolates

Comparative Study

Activity of ciprofloxacin against resistant clinical isolates

S G Kelley et al. J Antimicrob Chemother. 1986 Mar.

Abstract

The in-vitro activity of ciprofloxacin, a new quinolone derivative, was determined by broth microdilution for 518 clinical isolates. The MICs for 90% of the organisms were 2 mg/l for Pseudomonas aeruginosa, 8 mg/l for P. maltophilia, 4 mg/l for other Pseudomonas spp., 1 mg/l for Acinetobacter anitratus, 0.03-0.5 mg/l for differing species of Enterobacteriaceae, 2 mg/l for Streptococcus faecalis, 0.25 mg/l for coagulase-negative Staphylococcus spp. and 2 mg/l for S. aureus. Furthermore, on a weight basis, the activity of ciprofloxacin was equivalent or superior to that of cefotaxime, ceftazidime, gentamicin, imipenem, latamoxef, piperacillin, oxacillin and vancomycin. In general, ciprofloxacin appears to be highly active against organisms resistant to many broad spectrum antimicrobials, including norfloxacin, gentamicin, cefotaxime, and ceftazidime, with MICs for 90% of organisms in the range of 0.03 to 16 mg/l.

PubMed Disclaimer

Publication types