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. 1986 May 1;163(5):1314-8.
doi: 10.1084/jem.163.5.1314.

Gamma gene rearrangement and expression in autoreactive helper T cells

M Zauderer, A Iwamoto, T W Mak

Gamma gene rearrangement and expression in autoreactive helper T cells

M Zauderer et al. J Exp Med. .

Abstract

gamma gene rearrangements similar to those described for cytotoxic T cell lines are found in L3T4+, autoreactive, or KLH-specific cloned helper T cell lines. High levels of gamma RNA transcripts were, in addition, detected in four out of five L3T4+, class II MHC-specific, autoreactive T cell clones, and in at least one of three KLH-specific, class II MHC-restricted clones. This contrasts with previously reported (9) expression of gamma RNA in only 1 of 11 antigen-specific helper T cell lines.

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