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Review
. 2017 Sep-Dec;21(3):463-464.
doi: 10.4103/jomfp.JOMFP_158_17.

Metastasis: To and fro

Prachi Baldawa  1 , Pallavi Shirol  1 , Jyoti Alur  2 , Venkatesh V Kulkarni  3
Affiliations
Review

Metastasis: To and fro

Prachi Baldawa et al. J Oral Maxillofac Pathol. 2017 Sep-Dec.

Abstract

Cancer is one of the most life threatening diseases afflicting mankind. Oral carcinogenesis is a multifactorial process involving numerous genetic events that alter normal functions of oncogenes and tumour suppressor genes. These changes lead to a cell phenotype with increased cell proliferation, with loss of cell cohesion, and infiltration of adjacent tissue thus causing distant metastasis. The fact that cancer patients might develop metastasis after years or even decades from diagnosis of the primary tumor makes the metastatic process even more complex and the disease more deadly. The promise of this article is to enhance the understanding on molecular mechanisms underlying metastasis and provide a better approach towards development of novel therapeutic treatment modalities.

Keywords: Cancer; metastatic process; primary tumor.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Flowchart depicting role of E-cadherin in loss of cell to cell adhesion
Figure 2
Figure 2
Flowchart depicting role of Rho proteins in cell migration
See this image and copyright information in PMC

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