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Review
. 2018 Apr;17(2):e12734.
doi: 10.1111/acel.12734. Epub 2018 Feb 1.

Emerging roles of extracellular vesicles in cellular senescence and aging

Masaki Takasugi  1
Affiliations
Review

Emerging roles of extracellular vesicles in cellular senescence and aging

Masaki Takasugi. Aging Cell. 2018 Apr.

Abstract

Cellular senescence is a cellular program that prevents the proliferation of cells at risk of neoplastic transformation. On the other hand, age-related accumulation of senescent cells promotes aging at least partially due to the senescence-associated secretory phenotype, whereby cells secrete high levels of inflammatory cytokines, chemokines, and matrix metalloproteinases. Emerging evidence, however, indicates that extracellular vesicles (EVs) are important mediators of the effects of senescent cells on their microenvironment. Senescent cells secrete more EphA2 and DNA via EVs, which can promote cancer cell proliferation and inflammation, respectively. Extracellular vesicles secreted from DNA-damaged cells can also affect telomere regulation. Furthermore, it has now become clear that EVs actually play important roles in many aspects of aging. This review is intended to summarize these recent progresses, with emphasis on relationships between cellular senescence and EVs.

Keywords: EphA2; aging; cellular senescence; cytoplasmic DNA; extracellular vesicles; telomere.

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Figures

Figure 1
Figure 1
The functions of extracellular vesicles (EVs) secreted from DNA‐damaged, senescent, or aged cells
See this image and copyright information in PMC

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