Meddling with METTLs in Normal and Leukemia Stem Cells

Gaëlle H Martin¹, Christopher Y Park²

Affiliations

¹ Department of Pathology, New York University School of Medicine, New York, NY, USA.
² Department of Pathology, New York University School of Medicine, New York, NY, USA. Electronic address: christopher.park@nyumc.org.

PMID: 29395048
DOI: 10.1016/j.stem.2018.01.013

Free article

Comment

Meddling with METTLs in Normal and Leukemia Stem Cells

Gaëlle H Martin et al. Cell Stem Cell. 2018.

Free article

. 2018 Feb 1;22(2):139-141.

doi: 10.1016/j.stem.2018.01.013.

Authors

Gaëlle H Martin¹, Christopher Y Park²

Affiliations

¹ Department of Pathology, New York University School of Medicine, New York, NY, USA.
² Department of Pathology, New York University School of Medicine, New York, NY, USA. Electronic address: christopher.park@nyumc.org.

PMID: 29395048
DOI: 10.1016/j.stem.2018.01.013

Abstract

Three recent studies independently identified the m⁶A RNA modifying enzymes METTL3 and METTL14 as critical regulators of differentiation in both normal hematopoiesis and AML pathogenesis. These studies expand the described roles of the epitranscriptome in maintaining the undifferentiated state in somatic stem cells and human cancer.

PubMed Disclaimer

Comment on

The N⁶-methyladenosine (m⁶A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells.
Vu LP, Pickering BF, Cheng Y, Zaccara S, Nguyen D, Minuesa G, Chou T, Chow A, Saletore Y, MacKay M, Schulman J, Famulare C, Patel M, Klimek VM, Garrett-Bakelman FE, Melnick A, Carroll M, Mason CE, Jaffrey SR, Kharas MG. Vu LP, et al. Nat Med. 2017 Nov;23(11):1369-1376. doi: 10.1038/nm.4416. Epub 2017 Sep 18. Nat Med. 2017. PMID: 28920958 Free PMC article.
Promoter-bound METTL3 maintains myeloid leukaemia by m⁶A-dependent translation control.
Barbieri I, Tzelepis K, Pandolfini L, Shi J, Millán-Zambrano G, Robson SC, Aspris D, Migliori V, Bannister AJ, Han N, De Braekeleer E, Ponstingl H, Hendrick A, Vakoc CR, Vassiliou GS, Kouzarides T. Barbieri I, et al. Nature. 2017 Dec 7;552(7683):126-131. doi: 10.1038/nature24678. Epub 2017 Nov 27. Nature. 2017. PMID: 29186125 Free PMC article.
METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m⁶A Modification.
Weng H, Huang H, Wu H, Qin X, Zhao BS, Dong L, Shi H, Skibbe J, Shen C, Hu C, Sheng Y, Wang Y, Wunderlich M, Zhang B, Dore LC, Su R, Deng X, Ferchen K, Li C, Sun M, Lu Z, Jiang X, Marcucci G, Mulloy JC, Yang J, Qian Z, Wei M, He C, Chen J. Weng H, et al. Cell Stem Cell. 2018 Feb 1;22(2):191-205.e9. doi: 10.1016/j.stem.2017.11.016. Epub 2017 Dec 28. Cell Stem Cell. 2018. PMID: 29290617 Free PMC article.

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- Elsevier Science
Other Literature Sources
- scite Smart Citations
Medical
- MedlinePlus Health Information

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Meddling with METTLs in Normal and Leukemia Stem Cells

Affiliations

Meddling with METTLs in Normal and Leukemia Stem Cells

Authors

Affiliations

Abstract

Comment on

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical