Protein S-Nitrosylation: Enzymatically Controlled, but Intrinsically Unstable, Post-translational Modification

Abstract

Reports by Seth et al. (2018) and Wolhuter et al. (2018) in this issue of Molecular Cell highlight the enzymatic synthesis, functionality, and propagation of S-nitrosylation-based signaling and address its low stability due to the elevated reactivity toward other cellular thiols.