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Review
. 2018 Apr;28(4):255-257.
doi: 10.1016/j.tcb.2018.01.003. Epub 2018 Jan 31.

Novel Insights into NDP52 Autophagy Receptor Functioning

Christophe Viret  1 , Aurore Rozières  1 , Mathias Faure  2
Affiliations
Review

Novel Insights into NDP52 Autophagy Receptor Functioning

Christophe Viret et al. Trends Cell Biol. 2018 Apr.

Abstract

NDP52/CALCOCO2 makes multiple contributions to selective autophagy. By interacting with cargos and LC3, NDP52 directs autophagy targets to autophagosomes. In addition, NDP52 promotes autophagosomes fusion with endolysosomes by connecting autophagosomes to MYOSIN VI. Recent studies reveal that Rab35 GTPase controls NDP52 recruitment to its targets and that NDP52 triggers MYOSIN VI (MYO6) motility.

Keywords: NDP52; autophagosome; autophagy receptor; maturation; myosin VI; selective autophagy.

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