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Review
. 2018 Aug;111(8):1433-1448.
doi: 10.1007/s10482-018-1034-8. Epub 2018 Feb 3.

The 'gifted' actinomycete Streptomyces leeuwenhoekii

Jean Franco Castro  1 , Valeria Razmilic  1 , Juan Pablo Gomez-Escribano  2 , Barbara Andrews  1 , Juan Asenjo  1 , Mervyn Bibb  3
Affiliations
Review

The 'gifted' actinomycete Streptomyces leeuwenhoekii

Jean Franco Castro et al. Antonie Van Leeuwenhoek. 2018 Aug.

Abstract

Streptomyces leeuwenhoekii strains C34T, C38, C58 and C79 were isolated from a soil sample collected from the Chaxa Lagoon, located in the Salar de Atacama in northern Chile. These streptomycetes produce a variety of new specialised metabolites with antibiotic, anti-cancer and anti-inflammatory activities. Moreover, genome mining performed on two of these strains has revealed the presence of biosynthetic gene clusters with the potential to produce new specialised metabolites. This review focusses on this new clade of Streptomyces strains, summarises the literature and presents new information on strain C34T.

Keywords: Atacamycin; Chaxalactin; Chaxamycin; Lasso peptides; Specialised metabolites; Streptomyces leeuwenhoekii.

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