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Review
. 2018 Feb 28;16(1):7-17.
doi: 10.9758/cpn.2018.16.1.7.

Cognitive Deficits in Schizophrenia: Understanding the Biological Correlates and Remediation Strategies

Adarsh Tripathi  1 , Sujita Kumar Kar  1 , Rashmi Shukla  1
Affiliations
Review

Cognitive Deficits in Schizophrenia: Understanding the Biological Correlates and Remediation Strategies

Adarsh Tripathi et al. Clin Psychopharmacol Neurosci. .

Abstract

Cognitive deficits are one of the core symptoms of schizophrenia that evolve during the course of schizophrenia, after being originated even before the onset of illness. Existing pharmacological and biological treatment modalities fall short to meet the needs to improve the cognitive symptoms; hence, various cognitive remediation strategies have been adopted to address these deficits. Research evidences suggest that cognitive remediation measures improve the functioning, limit disability bettering the quality of life. The functional outcomes of cognitive remediation in schizophrenia are resultant of neurobiological changes in specific brain areas. Recent years witnessed significant innovations in cognitive remediation strategies in schizophrenia. This comprehensive review highlights the biological correlates of cognitive deficits in schizophrenia and the remedial measures with evidence base.

Keywords: Cognitive remediation; Cognitive symptoms; Neurobiology; Schizophrenia.

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Figures

Fig. 1
Fig. 1
Impact of cognitive deficits and role of cognitive remediation in schizophrenia.
See this image and copyright information in PMC

References

    1. Heinrichs RW, Zakzanis KK. Neurocognitive deficit in schizophrenia: a quantitative review of the evidence. Neuropsychology. 1998;12:426–445. doi: 10.1037/0894-4105.12.3.426. - DOI - PubMed
    1. Keefe RS, Eesley CE, Poe MP. Defining a cognitive function decrement in schizophrenia. Biol Psychiatry. 2005;57:688–691. doi: 10.1016/j.biopsych.2005.01.003. - DOI - PubMed
    1. Andreasen NC, Paradiso S, O’Leary DS. “Cognitive dysmetria” as an integrative theory of schizophrenia: a dysfunction in cortical-subcortical-cerebellar circuitry?”. Schizophr Bull. 1998;24:203–218. doi: 10.1093/oxfordjournals.schbul.a033321. - DOI - PubMed
    1. Häfner H, Riecher-Rössler A, Hambrecht M, Maurer K, Meissner S, Schmidtke A, et al. IRAOS: an instrument for the assessment of onset and early course of schizophrenia. Schizophr Res. 1992;6:209–223. doi: 10.1016/0920-9964(92)90004-O. - DOI - PubMed
    1. Rund BR. A review of longitudinal studies of cognitive functions in schizophrenia patients. Schizophr Bull. 1998;24:425–435. doi: 10.1093/oxfordjournals.schbul.a033337. - DOI - PubMed