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. 2018 Feb 28;16(1):39-45.
doi: 10.9758/cpn.2018.16.1.39.

Thiol Disulfide Homeostasis in Schizophrenic Patients Using Atypical Antipsychotic Drugs

Halef Okan Dogan  1 , Etem Erdal Ersan  2 , Hüseyin Aydin  1 , Serpil Erdoğan  3 , Serpil Erşan  1 , Murat Alişik  3 , Sevtap Bakir  1 , Özcan Erel  3 , Derya Koç  1
Affiliations

Thiol Disulfide Homeostasis in Schizophrenic Patients Using Atypical Antipsychotic Drugs

Halef Okan Dogan et al. Clin Psychopharmacol Neurosci. .

Abstract

Objective: Schizophrenia is a severe, debilitating mental disorder characterized by behavioral abnormalities. Although several studies have investigated the role of oxidative stress and the effects of antipsychotic drugs on oxidative markers in schizophrenia, adequate information is not available on these issues. The aim of this study is to determine the changes in oxidative status and thiol disulfide homeostasis in schizophrenic patients using atypical antipsychotic drugs.

Methods: Thirteen schizophrenic patients using atypical antipsychotic drugs and 30 healthy controls were included this study. The concentrations of total oxidant status (TOS), total antioxidant status (TAS), native thiol, total thiol, and disulfide levels were determined in the study population.

Results: The TAS (p=0.001), total thiol, and native thiol levels (p＜0.001) were higher in the patients compared to the controls, whereas the TOS and disulfide levels were lower in the patients than in the controls (p＜0.001).

Conclusion: These results may suggest that atypical antipsychotic drugs have a useful therapeutic effect by reducing oxidative stress via the inhibition of the formation of disulfide bonds. The study population number was one of the limitations of this study. Therefore, further studies are needed to establish the association between thiol disulfide homeostasis in schizophrenic patients using atypical antipsychotic drugs.

Keywords: Antipsychotics; Disulfides; Schizophrenia; Thiols.

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Figures

Fig. 1
Fig. 1
Box plots for TAS (A) and TOS (B) levels. The image of each group shows the box with median (horizontal line within the box); the interquartile range (IQR), corresponding to the 25th to 75th percentiles (lower and upper limit of the box); nearest observations within 1.5 IQRs (the whiskers) and outliers (circles within 3 IQR). TAS, total antioxidant status; TOS, total oxidant status.
Fig. 2
Fig. 2
Box plots for native thiol levels (A), total thiol levels (B) and disulphide levels (C). The image of each group shows the box with median (horizontal line within the box); the interquartile range (IQR), corresponding to the 25th to 75th percentiles (lower and upper limit of the box); nearest observations within 1.5 IQRs (the whiskers) and outliers (circles within 3 IQR).
See this image and copyright information in PMC

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