The Many Worlds of Plasticity Rules
- PMID: 29397991
- DOI: 10.1016/j.tins.2018.01.006
The Many Worlds of Plasticity Rules
Abstract
Two recent papers have tackled the fundamental questions of how place fields are formed in a new environment and what plasticity mechanisms contribute to this process. Bittner et al., in their recent publication, discovered a novel plasticity rule that, in contrast to previous rules, spans the behavioral, seconds-long, timescale. Sheffield et al. have monitored, for the first time, dendritic activity during place field formation, and show the emergence of spatially tuned local NMDA spikes in basal dendrites of CA1 neurons. Together, these papers suggest that multiple complementary dendritic plasticity mechanisms may contribute to place field formation in changing environmental contexts.
Keywords: LTP; dendrites; hippocampus; place cells; plasticity; spikes.
Copyright © 2018 Elsevier Ltd. All rights reserved.
Comment on
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Behavioral time scale synaptic plasticity underlies CA1 place fields.Science. 2017 Sep 8;357(6355):1033-1036. doi: 10.1126/science.aan3846. Science. 2017. PMID: 28883072 Free PMC article.
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Increased Prevalence of Calcium Transients across the Dendritic Arbor during Place Field Formation.Neuron. 2017 Oct 11;96(2):490-504.e5. doi: 10.1016/j.neuron.2017.09.029. Neuron. 2017. PMID: 29024668 Free PMC article.
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