Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Jan;15(1):979-983.
doi: 10.3892/ol.2017.7439. Epub 2017 Nov 17.

Triple negative breast cancer and immunoglobulin A nephropathy: A case report and literature review

Da Jiang  1 , Xue Zhang  1 , Jiayin Liu  1 , Yanzhi Cui  1 , Ying Li  1 , Fei Zheng  1
Affiliations

Triple negative breast cancer and immunoglobulin A nephropathy: A case report and literature review

Da Jiang et al. Oncol Lett. 2018 Jan.

Abstract

The association between malignant tumors and the occurrence of glomerular disease has been well documented in previous studies. The most common types of malignant tumor include Hodgkin's lymphoma with minimal change glomerular nephritis, solid tumor with membranous nephropathy and renal cell carcinoma with immunoglobulin (Ig)A nephropathy. The present case study describes a case of a 31-year-old Chinese female patient who was hospitalized with chronic glomerulonephritis. The patient self-administered unknown traditional Chinese medicine; however, protein excretion/24-h remained increased compared with normal levels. After 34 months, a tumor was identified in the patient. Subsequently, the patient was administered breast-conserving surgery and sentinel lymph node biopsy, which validated the diagnosis of triple negative breast cancer at stage IA (T1cN0M0). The patient received chemotherapy and radiotherapy. Following the review of the relevant studies within the last 30 years, it was demonstrated that the present report was the second documented case of breast cancer associated with IgA nephropathy. Thus, the present study hypothesized that IgA nephropathy may be a tumor manifestation in breast cancer.

Keywords: immunoglobulin A nephropathy; primary glomerular disease; triple negative breast cancer.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Focal proliferative IgA nephropathy (Lee grading, III) (27) was diagnosed using electron microscopy. In accordance with the Oxford classification (28) of IgA nephropathy, it was equivalent to M1 E0 S1 T0. IgA, immunoglobulin A.
Figure 2.
Figure 2.
Pathological examination or renal tissue using optical microscopy. (A) Glomerular sclerosis indicated by hematoxylin and eosin staining. (B) Glomerular segmental sclerosis indicated by periodic acid-silver metheramine. (C) Glomerular balloon adhesion indicated by periodic acid-Shiff staining. (D) Immunoglobulin A deposition indicated by immunofluorescence detection of paraffin-embedded sections. Points of interest pertaining to each description are indicated with a red arrow. Magnification, ×400.
See this image and copyright information in PMC

References

    1. Galloway J. Remarks on Hodgkin's disease. Br Med J. 1922;2:1201–1208. doi: 10.1136/bmj.2.3234.1201. - DOI - PMC - PubMed
    1. Lee JC, Yamauchi H, Hopper J., Jr The association of cancer and the nephritic syndrome. Ann Intern Med. 1966;64:41–51. doi: 10.7326/0003-4819-64-1-41. - DOI - PubMed
    1. Yin P, Chen W, Chen G. Clinical report of 4 cases of malignant tumor complicated with glomerular disease. New Med. 1986;7:354–355.
    1. Pani A, Porta C, Cosmai L, Melis P, Floris M, Piras D, Gallieni M, Rosner M, Ponticelli C. Glomerular diseases and cancer: Evaluation of underlying malignancy. J Nephrol. 2016;29:143–152. doi: 10.1007/s40620-015-0234-9. - DOI - PMC - PubMed
    1. Tanaka K, Kanzaki H, Taguchi T. IgA glomerulonephtitis in a patient with renal cell carcinoma. Nippon Jinzo Gakkai Shi. 1991;33:87–90. - PubMed