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. 2018 Feb 5;18(1):27.
doi: 10.1186/s12886-018-0698-1.

Effect of oral Colchicine on Peripapillary retinal nerve fiber layer thickness in patients with familial Mediterranean fever

Burak Tanyıldız  1 , Mehmet Engin Tezcan  2 , Baran Kandemir  3 , Nesrin Tutaş Günaydın  3 , Eren Göktaş  3 , Aise Tangılntız  4 , Aysu Karatay Arsan  3
Affiliations

Effect of oral Colchicine on Peripapillary retinal nerve fiber layer thickness in patients with familial Mediterranean fever

Burak Tanyıldız et al. BMC Ophthalmol. .

Abstract

Background: The purpose of this study is to investigate whether oral colchicine has an effect on peripapillary retinal nerve fiber layer (pRNFL) thickness of familial Mediterranean fever (FMF) patients.

Methods: We conducted a cross sectional study by comparing pRNFL thickness of FMF patients on colchicine (treated group), newly diagnosed colchicine naïve FMF patients (untreated group) and healthy controls. The study included 66 FMF patients and 32 healthy control subjects. Treated FMF patients were grouped according to colchicine use, duration of use and dosage. pRNFL thickness of the patients and controls were measured by using optical coherence tomography and the measurements were compared.

Results: No statistically significant difference was found between the pRNFL thickness in untreated group, treated group and the healthy control group (all p > 0.05). No statistically significant difference was found between pRNFL thickness in the healthy control group and FMF patients grouped according to duration or dosage of colchicine use (all p > 0.05).

Conclusions: According to our study, FMF and oral colchicine use had no statistically significant effect on pRNFL thickness.

Keywords: Colchicine; Familial Mediterranean fever; Optic coherence tomography; Peripapillary retinal nerve fiber layer thickness.

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Conflict of interest statement

Ethics approval and consent to participate

The Institutional Review Board and Ethics Committee of the Dr. Lutfi Kirdar Kartal Education and Research Hospital approved the initiation of the study (IRB No: 2017/514/105/1). Informed written consent was obtained from all individual participants in the study.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Peripapillary RNFL analysis with OCT in a patient with FMF. The RNFL thickness (inferior, superior, nasal, temporal quadrants and average) is measured around a 3.4 mm diameter circle centered on the optic disc
See this image and copyright information in PMC

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