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Comparative Study
. 2018 Mar;48(2):141-144.
doi: 10.1016/j.medmal.2018.01.001.

Intensive care admission for Coronavirus OC43 respiratory tract infections

D Vandroux  1 , N Allou  2 , J Jabot  2 , G Li Pat Yuen  3 , E Brottet  4 , B Roquebert  5 , O Martinet  2
Affiliations
Comparative Study

Intensive care admission for Coronavirus OC43 respiratory tract infections

D Vandroux et al. Med Mal Infect. 2018 Mar.

Abstract
in English, French

Background: Coronavirus OC43 infection causes severe pneumonia in patients presenting with comorbidities, but clinical signs alone do not allow for viral identification.

Objectives: To analyze acute manifestations of Coronavirus OC43 infections and outcomes of patients admitted to an intensive care unit (ICU).

Patients and methods: Retrospective and monocentric study performed during a Coronavirus OC43 outbreak. We used multiplex PCR to detect an OC43 outbreak in Reunion Island during the 2016 Southern Hemisphere's winter: seven admissions to the ICU.

Results: Mean age of patients was 71 [67;76] years, SAPS II was 42 [28;53], pneumonia severity index 159 [139;182] vs 73 [40.5;107] for patients in medical wards, and 43% required mechanical ventilation. Comorbidities were diabetes mellitus (87%), chronic respiratory failure (57%), and chronic renal failure (29%). One patient died from Haemophilus influenzae co-infection.

Conclusion: As for MERS Co-V infections, underlying comorbidities impacted the clinical outcomes of OC43 infections.

Introduction: L’infection à Coronavirus OC43 peut induire des pneumopathies sévères chez les patients présentant des comorbidités lors d’épisodes hivernaux en climat tempéré.

Patients et méthodes: Analyse rétrospective, monocentrique des cas d’infections à Coronavirus OC43 admis en réanimation. L’utilisation d’une PCR multiplex pour les infections respiratoires a permis de détecter une épidémie de bronchopneumopathies à Coronavirus OC43 durant l’hiver austral 2016 à La Réunion: sept admissions en réanimation.

Résultats: Des patients, âgés de 71 [67 ; 76] ans en moyenne, présentaient un indice de gravité simplifié II de 42 [28 ; 53] et une ventilation mécanique était requise pour 43 %. Les comorbidités comprenaient diabète (87 %), insuffisance respiratoire chronique (57 %) et insuffisance rénale chronique (29 %). Un décès est survenu au cours d’une co-infection à Haemophilus influenzae.

Conclusion: Comme pour le MERS Coronavirus, les comorbidités impactent l’évolution clinique d’une infection et conduisent à des admissions en réanimation.

Keywords: Coronavirus OC43; PCR multiplex; multiplex PCR.

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Figures

Fig. 1
Fig. 1
Flow chart describing ICU admissions in Saint-Denis, Reunion Island, with the proportion of respiratory samples for PCR multiplex and the proportion of mechanical ventilation during the influenza season (June 15, 2016–September 30, 2016). Flux des patients admis en réanimation polyvalente à Saint-Denis-de-La-Réunion avec la proportion de tests PCR multiplex et de ventilation mécanique pendant la saison grippale d’hiver austral (15 juin 2016–30 septembre 2016).
See this image and copyright information in PMC

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