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Comment
. 2018 Mar;24(3):237-239.
doi: 10.1016/j.molmed.2018.01.007. Epub 2018 Feb 3.

Bone Talk: Activated Osteoblasts Promote Lung Cancer Growth

Emilis Bružas  1 , Mikala Egeblad  2
Affiliations
Comment

Bone Talk: Activated Osteoblasts Promote Lung Cancer Growth

Emilis Bružas et al. Trends Mol Med. 2018 Mar.

Abstract

Cancer cells can directly stimulate the generation and recruitment of tumor-supportive bone marrow-derived cells (BMDCs), including neutrophils, via secreted factors. A new study demonstrates that lung tumors also remotely activate bone-residing osteoblasts, which in turn promote neutrophil production. This is a multistep mechanism of establishing a supportive tumor microenvironment.

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  • Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils.
    Engblom C, Pfirschke C, Zilionis R, Da Silva Martins J, Bos SA, Courties G, Rickelt S, Severe N, Baryawno N, Faget J, Savova V, Zemmour D, Kline J, Siwicki M, Garris C, Pucci F, Liao HW, Lin YJ, Newton A, Yaghi OK, Iwamoto Y, Tricot B, Wojtkiewicz GR, Nahrendorf M, Cortez-Retamozo V, Meylan E, Hynes RO, Demay M, Klein A, Bredella MA, Scadden DT, Weissleder R, Pittet MJ. Engblom C, et al. Science. 2017 Dec 1;358(6367):eaal5081. doi: 10.1126/science.aal5081. Science. 2017. PMID: 29191879 Free PMC article.

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