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Meta-Analysis
. 2018;8(1):1-15.
doi: 10.1159/000484989. Epub 2018 Jan 9.

Oral Health and Brain Injury: Causal or Casual Relation?

Rajath Sasidharan Pillai  1 , Kiran Iyer  2 , Rubens Spin-Neto  3 , Simple Futarmal Kothari  1 , Jørgen Feldbæk Nielsen  4 , Mohit Kothari  4
Affiliations
Meta-Analysis

Oral Health and Brain Injury: Causal or Casual Relation?

Rajath Sasidharan Pillai et al. Cerebrovasc Dis Extra. 2018.

Abstract

Background: To systematically review the current literature investigating the association between oral health and acquired brain injury.

Methods: A structured search strategy was applied to PubMed, Embase, Web of Science, and CENTRAL electronic databases until March 2017 by 2 independent reviewers. The preferred reporting items for systematic review and meta-analysis guidelines were used for systematic review.

Results: Even though the objective was to assess the association between oral health and acquired brain injury, eligible studies focused solely on different forms of stroke and stroke subtypes. Stroke prediction was associated with various factors such as number of teeth, periodontal conditions (even after controlling for confounding factors), clinical attachment loss, antibody levels to Aggregatibacter actinomycetemcomitans and Prevotella intermedia. The literature showed no consensus on the possible association between gingivitis and stroke. Patients with stroke generally had poorer oral hygiene practices and oral health. Dental prophylaxis and professional intervention reduced the incidence of stroke.

Conclusions: Overall, oral health and stroke were related. Periodontitis and tooth loss were independently associated with stroke. However, prevention and timely intervention may reduce the risk of stroke. Stroke was the main cerebral lesion studied in the literature, with almost no publications on other brain lesions.

Keywords: Brain injury; Cerebrovascular disorders; Oral hygiene; Oro-dental condition; Periodontitis.

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Figures

Fig. 1.
Fig. 1.
PRISMA 2009 flow diagram regarding paper selection.
See this image and copyright information in PMC

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References

    1. Dörfer CE, Becher H, Ziegler CM, Kaiser C, Lutz R, Jörss D, et al. The association of gingivitis and periodontitis with ischemic stroke. J Clin Periodontol. 2004;31:396–401. - PubMed
    1. Miniño AM, Arias E, Kochanek KD, Murphy SL, Smith BL. Deaths: final data for 2000. Natl Vital Stat Rep. 2002;50:1–119. - PubMed
    1. Joshipura KJ, Hung H-C, Rimm EB, Willett WC, Ascherio A. Periodontal disease, tooth loss, and incidence of ischemic stroke. Stroke J Cereb Circ. 2003;34:47–52. - PubMed
    1. Oluwagbemigun K, Dietrich T, Pischon N, Bergmann M, Boeing H. Association between number of teeth and chronic systemic diseases: a cohort study followed for 13 years. PLoS One. 2015;10:e0123879. - PMC - PubMed
    1. Syrjänen J, Peltola J, Valtonen V, Iivanainen M, Kaste M, Huttunen JK. Dental infections in association with cerebral infarction in young and middle-aged men. J Intern Med. 1989;225:179–184. - PubMed

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