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. 2012 Oct;2(5):386-389.
doi: 10.1016/j.jpha.2012.06.002. Epub 2012 Jun 27.

Monitoring the hydrolyzation of aspirin during the dissolution testing for aspirin delayed-release tablets with a fiber-optic dissolution system

Yan Wang  1 , Ping-Ping Xu  1 , Xin-Xia Li  1 , Kun Nie  1 , Ming-Fu Tuo  1 , Bin Kong  2 , Jian Chen  1
Affiliations

Monitoring the hydrolyzation of aspirin during the dissolution testing for aspirin delayed-release tablets with a fiber-optic dissolution system

Yan Wang et al. J Pharm Anal. 2012 Oct.

Abstract

The purpose of this study was to investigate the hydrolyzation of aspirin during the process of dissolution testing for aspirin delayed-release tablets. Hydrolysis product of salicylic acid can result in adverse effects and affect the determination of dissolution rate assaying. In this study, the technique of differential spectra was employed, which made it possible to monitor the dissolution testing in situ. The results showed that the hydrolyzation of aspirin made the percentage of salicylic acid exceed the limit of free salicylic acid (4.0), and the hydrolyzation may affect the quality detection of aspirin delayed-release tablets.

Keywords: Aspirin delayed-release tablets; Drug dissolution test; Fiber-optic dissolution system; UV–vis spectrum.

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Figures

Figure 1
Figure 1
UV absorbance spectra of salicylic acids and aspirin.
Figure 2
Figure 2
Release profiles of aspirin delayed-release tablets.
Figure 3
Figure 3
UV absorbance spectra of aspirin at different time points.
None
See this image and copyright information in PMC

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