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. 2017 Oct;7(5):332-337.
doi: 10.1016/j.jpha.2017.03.006. Epub 2017 Mar 22.

In-depth investigation on physicochemical and thermal properties of magnesium (II) gluconate using spectroscopic and thermoanalytical techniques

Mahendra Kumar Trivedi  1 , Neena Dixit  2 , Parthasarathi Panda  3 , Kalyan Kumar Sethi  3 , Snehasis Jana  3
Affiliations

In-depth investigation on physicochemical and thermal properties of magnesium (II) gluconate using spectroscopic and thermoanalytical techniques

Mahendra Kumar Trivedi et al. J Pharm Anal. 2017 Oct.

Abstract

Magnesium gluconate is a classical organometallic pharmaceutical compound used for the prevention and treatment of hypomagnesemia as a source of magnesium ion. The present research described the in-depth study on solid state properties viz. physicochemical and thermal properties of magnesium gluconate using sophisticated analytical techniques like PXRD, PSA, FT-IR, UV-Vis spectroscopy, TGA/DTG, and DSC. Magnesium gluconate was found to be crystalline in nature along with the crystallite size ranging from 14.10 to 47.35 nm. The particle size distribution was at d(0.1)=6.552 µm, d(0.5)=38.299 µm, d(0.9)=173.712 µm and D(4,3)=67.122 µm along with the specific surface area of 0.372 m2/g. The wavelength for the maximum absorbance was at 198.0 nm. Magnesium gluconate exhibited 88.51% weight loss with three stages of thermal degradation process up to 895.18 °C from room temperature. The TGA/DTG thermograms of the analyte indicated that magnesium gluconate was thermally stable up to around 165 °C. Consequently, the melting temperature of magnesium gluconate was found to be 169.90 °C along with the enthalpy of fusion of 308.7 J/g. Thus, the authors conclude that the achieved results from this study are very useful in pharmaceutical and nutraceutical industries for the identification, characterization and qualitative analysis of magnesium gluconate for preformulation studies and also for developing magnesium gluconate based novel formulation.

Keywords: Magnesium gluconate; Particle size analysis; Solid state properties; Spectroscopic analysis; Thermal analysis.

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Figures

Fig. 1
Fig. 1
Powder X-ray diffraction pattern of magnesium gluconate.
Fig. 2
Fig. 2
FT-IR spectrum of magnesium gluconate.
Fig. 3
Fig. 3
Structure of magnesium gluconate.
Fig. 4
Fig. 4
UV–Vis spectrum of magnesium (II) gluconate.
Fig. 5
Fig. 5
(A) TGA thermogram and (B) DTG thermogram of magnesium gluconate.
Fig. 6
Fig. 6
DSC thermogram of magnesium gluconate.
See this image and copyright information in PMC

References

    1. Ramachandran S., Fontanille P., Pandey A. Gluconic acid: properties, applications and microbial production. Food Technol. Biotechnol. 2006;44:185–195.
    1. Choi M.K., Weaver C.M. Daily intake of magnesium and its relation to urinary excretion in Korean healthy adults consuming self-selected diets. Biol. Trace Elem. Res. 2017;176:105–113. - PubMed
    1. Ponka R., Fokou E., Beaucher E. Nutrient content of some Cameroonian traditional dishes and their potential contribution to dietary reference intakes. Food Sci. Nutr. 2016;4:696–705. - PMC - PubMed
    1. Birch N.J. Magnesium in biology and medicine: an overview in Metal ions in biological systems. In: Sigel H., Sigel A., editors. Vol. 26. Marcel Dekker Inc; New York: 1990. pp. 105–115. (Compendium on Magnesium and its Role in Biology, Nutrition and Physiology).
    1. William J.H., Danziger J. Magnesium deficiency and proton-pump inhibitor use: a clinical review. J. Clin. Pharmacol. 2016;56:660–668. - PubMed