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Randomized Controlled Trial
. 2018 Aug;32(8):3533-3539.
doi: 10.1007/s00464-018-6075-6. Epub 2018 Feb 5.

Evaluation of 22G fine-needle aspiration (FNA) versus fine-needle biopsy (FNB) for endoscopic ultrasound-guided sampling of pancreatic lesions: a prospective comparison study

Li Tian  1 , An-Liu Tang  1   2 , Lei Zhang  3 , Xiao-Wen Liu  3 , Jing-Bo Li  1 , Fen Wang  1   2 , Shou-Rong Shen  1   2 , Xiao-Yan Wang  4   5
Affiliations
Randomized Controlled Trial

Evaluation of 22G fine-needle aspiration (FNA) versus fine-needle biopsy (FNB) for endoscopic ultrasound-guided sampling of pancreatic lesions: a prospective comparison study

Li Tian et al. Surg Endosc. 2018 Aug.

Erratum in

Abstract

Background: To compare the diagnostic yield and safety of 22G endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) and endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) in the diagnosis of pancreatic solid lesions.

Methods: Between April 2014 and September 2015, 36 patients with pancreatic solid lesions were included for endoscopic ultrasound test. Patients were randomly divided into two groups: EUS-FNA (n = 18) and EUS-FNB (n = 18). Each nidus was punctured three times (15 ~ 20 insertions for each puncture) with a 22G needle. The core specimens were analyzed, and the diagnostic yields of FNA and FNB were evaluated.

Results: The procedure success rate was 100% with no complications. Cytological and histological examinations found that the diagnostic yield of FNB and FNA were both 83.3%. To get a definitive diagnosis, FNB needed fewer punctures than FNA (1.11 vs. 1.83; P < 0.05).

Conclusions: 22G EUS-FNB is a safe and effective way to diagnose pancreatic solid lesions. FNB required a lower number of needle passes to achieve a diagnosis compared with FNA.

Keywords: Pancreatic solid lesion; Ultrasound-guided fine-needle aspiration; Ultrasound-guided fine-needle biopsy.

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Conflict of interest statement

Dr. Li Tian, Dr. An-liu Tang, Dr. Lei Zhang, Dr. Xiao-wen Liu, Dr. Jing-bo Li, Prof. Fen Wang, Prof. Shou-rong Shen, and Prof. Xiao-yan Wang have no conflicts of interest or financial ties to disclose.

Figures

Fig. 1
Fig. 1
EUS-guided biopsy from pancreatic solid masses using FNA (A) and FNB (B)
Fig. 2
Fig. 2
Tissue core obtained using the 22G fine-needle biopsy needle by EUS-FNA (A) and FNB (B)
Fig. 3
Fig. 3
Histological evaluation of specimens obtained (hematoxylin & eosin [H&E] staining). A pancreatic ductal adenocarcinoma, sample obtained using the new 22G fine-needle biopsy needle by EUS-FNA. B pancreatic ductal adenocarcinoma, sample obtained using standard fine-needle aspiration needle by EUS-FNB
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