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. 2018 May;12(5):E256-E259.
doi: 10.5489/cuaj.4860. Epub 2018 Feb 6.

Case - Foamy, high-grade prostatic intraepithelial neoplasia: A false positive for prostate cancer on multiparametric magnetic resonance imaging?

Thenappan Chandrasekar  1 , Hanan Goldberg  1 , Zachary Klaassen  1 , Nathan Perlis  1 , Antonio Finelli  1 , Andrew Evans  2 , Sangeet Ghai  3
Affiliations

Case - Foamy, high-grade prostatic intraepithelial neoplasia: A false positive for prostate cancer on multiparametric magnetic resonance imaging?

Thenappan Chandrasekar et al. Can Urol Assoc J. 2018 May.
No abstract available

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Conflict of interest statement

Competing interests: The authors report no competing personal or financial interests related to this work.

Figures

Fig. 1
Fig. 1
Multiparametric magnetic resonance (MR) imaging findings of foamy prostatic intraepithelial neoplasia. (A, B) Axial T2-weighted fast spin-echo MR image (TR/TE, 4140/97). (C, D) Corresponding axial apparent diffusion coefficient (ADC) map (TR/TE, 4800/70; b values 100, 400, 800, 1000 mm/s2).
Fig. 2
Fig. 2
Classic histological features of foamy, high-grade prostatic intraepithelial neoplasia. (A) Low magnification (50x) overview of a biopsy core from the “left magnetic resonance imaging nodule” in the original biopsy performed in January 2016. The core is extensively involved by foamy gland high-grade prostatic intraepithelial neoplasia (HG PIN). (B) Medium magnification (100x) micrograph showing prostatic glands lined by cells with abundant xanthomatous cytoplasm with a distinct foamy appearance and uniform nuclei. Papillary infolding is apparent, however, the involved glands are not completely filled by the foamy cells. (C) High magnification micrograph (400x) showing the presence of cells with macronucleoli within the foamy gland HG PIN. (D) Immunohistochemical staining with high molecular weight cytokeratin (34βE12) demonstrates the presence of a discontinuous layer of basal cells (200x).
Fig. 2
Fig. 2
Classic histological features of foamy, high-grade prostatic intraepithelial neoplasia. (A) Low magnification (50x) overview of a biopsy core from the “left magnetic resonance imaging nodule” in the original biopsy performed in January 2016. The core is extensively involved by foamy gland high-grade prostatic intraepithelial neoplasia (HG PIN). (B) Medium magnification (100x) micrograph showing prostatic glands lined by cells with abundant xanthomatous cytoplasm with a distinct foamy appearance and uniform nuclei. Papillary infolding is apparent, however, the involved glands are not completely filled by the foamy cells. (C) High magnification micrograph (400x) showing the presence of cells with macronucleoli within the foamy gland HG PIN. (D) Immunohistochemical staining with high molecular weight cytokeratin (34βE12) demonstrates the presence of a discontinuous layer of basal cells (200x).
Fig. 2
Fig. 2
Classic histological features of foamy, high-grade prostatic intraepithelial neoplasia. (A) Low magnification (50x) overview of a biopsy core from the “left magnetic resonance imaging nodule” in the original biopsy performed in January 2016. The core is extensively involved by foamy gland high-grade prostatic intraepithelial neoplasia (HG PIN). (B) Medium magnification (100x) micrograph showing prostatic glands lined by cells with abundant xanthomatous cytoplasm with a distinct foamy appearance and uniform nuclei. Papillary infolding is apparent, however, the involved glands are not completely filled by the foamy cells. (C) High magnification micrograph (400x) showing the presence of cells with macronucleoli within the foamy gland HG PIN. (D) Immunohistochemical staining with high molecular weight cytokeratin (34βE12) demonstrates the presence of a discontinuous layer of basal cells (200x).
Fig. 2
Fig. 2
Classic histological features of foamy, high-grade prostatic intraepithelial neoplasia. (A) Low magnification (50x) overview of a biopsy core from the “left magnetic resonance imaging nodule” in the original biopsy performed in January 2016. The core is extensively involved by foamy gland high-grade prostatic intraepithelial neoplasia (HG PIN). (B) Medium magnification (100x) micrograph showing prostatic glands lined by cells with abundant xanthomatous cytoplasm with a distinct foamy appearance and uniform nuclei. Papillary infolding is apparent, however, the involved glands are not completely filled by the foamy cells. (C) High magnification micrograph (400x) showing the presence of cells with macronucleoli within the foamy gland HG PIN. (D) Immunohistochemical staining with high molecular weight cytokeratin (34βE12) demonstrates the presence of a discontinuous layer of basal cells (200x).
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