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Review
. 2017 May;24(5S2):5S93-5S95.
doi: 10.1016/S0929-693X(18)30023-X.

Renal impairment in hypophosphatasia

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Review

Renal impairment in hypophosphatasia

J Bacchetta. Arch Pediatr. 2017 May.

Abstract

Renal impairment in hypophosphatasia (HPP) has been described but remains poorly understood: hypercalciuria, nephrocalcinosis and sometimes even chronic kidney failure secondary to chronic hypercalcemia/hypercalciuria or exposure to toxic agents. The objectives of this review are to describe the different renal lesions observed in HPP, and the therapeutic measures that can be applied (in particular, thiazide diuretics).

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