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Review
. 2018 Mar;45(1):75-91.
doi: 10.1016/j.clp.2017.11.001.

Congenital Hypopituitarism

John S Parks  1
Affiliations
Review

Congenital Hypopituitarism

John S Parks. Clin Perinatol. 2018 Mar.

Abstract

Mutations of growth hormone genes and pituitary transcription factors account for a small proportion of cases of severe congenital hypopituitarism. Most cases show characteristic MRI findings of pituitary stalk interruption syndrome. Clinical suspicion should prompt assessment of cortisol, free T4, thyroid-stimulating hormone, and growth hormone levels together with MRI of the hypothalamic and pituitary regions.

Keywords: Cholestasis; Growth hormone; Guidelines; Hypoglycemia; Hypopituitarism; MRI; Pituitary stalk.

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