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. 2018 Mar 15:386:23-28.
doi: 10.1016/j.jns.2017.12.032. Epub 2018 Jan 4.

Feasibility study of a targeted self-management intervention for reducing stroke risk factors in a high-risk population in Uganda

Mark Kaddumukasa  1 , Jane Nakibuuka  2 , Levicatus Mugenyi  2 , Olivia Namusoke  2 , Doreen Birungi  2 , Bryan Kabaala  2 , Carol Blixen  3 , Elly Katabira  4 , Anthony Furlan  5 , Martha Sajatovic  6
Affiliations

Feasibility study of a targeted self-management intervention for reducing stroke risk factors in a high-risk population in Uganda

Mark Kaddumukasa et al. J Neurol Sci. .

Abstract

Introduction: Stroke remains a global concern due to increasing lifespan, patterns of industrialization, adoption of harmful western diets, and an increasing prevalence of risk factors such as hypertension, obesity, and diabetes. We investigated an adopted novel self-management intervention, TargetEd mAnageMent Intervention (TEAM) to reduce modifiable stroke risk factors in Uganda.

Methods: A six-month, uncontrolled, prospective pilot study to establish feasibility, acceptability and preliminary efficacy of TEAM in Ugandans at high risk for stroke was conducted. The primary outcome was change in systolic BP from baseline to 24-week follow-up. Secondary outcomes included change in diastolic BP, serum cholesterol, high and low density lipoprotein (HDL, LDL) and triglycerides.

Results: Mean (SD) baseline systolic BP was 162.9 (±25.6) mmHg while mean (SD) baseline diastolic BP was 99.1 (±13.8) mmHg. There was a significant reduction in mean baseline blood pressure of 163/98.8mmHg to blood pressure of 147.8/88.0mmHg at 24weeks, P=0.023. There were also significant reductions in the serum total cholesterol levels at 24weeks with P=0.001.

Conclusion: Targeted training in self-management (TEAM) adapted to the Ugandan setting is feasible, highly acceptable to participants and appears to be associated with reduced blood pressure, improved lipid profiles and improved glucose control in diabetics.

Keywords: Blood pressure; Prevention; Risk factors; Stroke.

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Conflict of interest statement

Competing Interests

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
Change patterns in systolic and diastolic blood pressure from base line to 12 and 24 weeks with 95% confidence intervals as dotted lines
See this image and copyright information in PMC

References

    1. Feigin VL, Forouzanfar MH, Krishnamurthi R, Mensah GA, Connor M, Bennett DA, et al. Global and regional burden of stroke during 1990-2010: findings from the Global Burden of Disease Study 2010. Lancet. 2014;383(9913):245–54. - PMC - PubMed
    1. Chin JH. Stroke in sub-Saharan Africa: an urgent call for prevention. Neurology. 2012;78(13):1007–8. - PubMed
    1. Beaglehole R, Bonita R, Alleyne G, Horton R, Li L, Lincoln P, et al. UN High-Level Meeting on Non-Communicable Diseases: addressing four questions. Lancet. 2011;378(9789):449–55. - PubMed
    1. Strong K, Mathers C, Bonita R. Preventing stroke: saving lives around the world. Lancet neurology. 2007;6(2):182–7. - PubMed
    1. Organization WH. Global Burden of Disease (GBD) 2004 update. Geneva, Switzerland: WHO; 2008.

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