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Review
. 2018 Mar;47(1):81-96.
doi: 10.1016/j.ecl.2017.10.002.

Intensive Blood Glucose Control and Vascular Outcomes in Patients with Type 2 Diabetes Mellitus

Marian Sue Kirkman  1 , Hussain Mahmud  2 , Mary T Korytkowski  3
Affiliations
Review

Intensive Blood Glucose Control and Vascular Outcomes in Patients with Type 2 Diabetes Mellitus

Marian Sue Kirkman et al. Endocrinol Metab Clin North Am. 2018 Mar.

Abstract

People with type 2 diabetes mellitus are at high risk of morbidity and mortality from cardiovascular disease (CVD). Based on observed relationships between hyperglycemia and CVD, several large clinical trials have investigated the ability of treatment strategies to achieve hemoglobin A1c less than 7% (53 mmol/mol) as a way of reducing this risk. These studies demonstrate that intensified glycemic therapy may reduce CVD risk in younger patients with recent-onset type 2 diabetes mellitus but not in high-risk older individuals with established disease. Attention to blood pressure and lipid-lowering therapies with modified glycemic goals for older high-risk individuals is recommended.

Keywords: Cardiovascular disease; Glycemic control; Hypoglycemia; Type 2 diabetes mellitus.

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