Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Observational Study
. 2018 Apr 15;124(8):1828-1838.
doi: 10.1002/cncr.31240. Epub 2018 Feb 6.

Psychometric evaluation and adaptation of the Spine Oncology Study Group Outcomes Questionnaire to evaluate health-related quality of life in patients with spinal metastases

Anne L Versteeg  1 , Arjun Sahgal  2 , Laurence D Rhines  3 , Daniel M Sciubba  4 , James M Schuster  5 , Michael H Weber  6 , Peter Pal Varga  7 , Stefano Boriani  8 , Chetan Bettegowda  4 , Michael G Fehlings  9 , Michelle J Clarke  10 , Paul M Arnold  11 , Ziya L Gokaslan  12 , Charles G Fisher  13 ; AOSpine Knowledge Forum Tumor  14
Affiliations
Observational Study

Psychometric evaluation and adaptation of the Spine Oncology Study Group Outcomes Questionnaire to evaluate health-related quality of life in patients with spinal metastases

Anne L Versteeg et al. Cancer. .

Abstract

Background: The Spine Oncology Study Group Outcomes Questionnaire (SOSGOQ) was developed as the first spine oncology-specific health-related quality of life (HRQOL) measure. This study evaluated the psychometric properties and clinical validity of the SOSGOQ in a diverse cohort of patients with spinal metastases.

Methods: An international, multicenter, prospective observational cohort study including patients with spinal metastases who underwent surgery and/or radiotherapy was conducted by the AOSpine Knowledge Forum Tumor. Demographic, tumor, and treatment data were collected. HRQOL was evaluated using the SOSGOQ and Medical Outcomes Study Questionnaire Short Form 36 Health Survey (SF-36) at baseline and fixed follow-up times. Construct validity was assessed using multitrait scaling analyses, confirmatory factor analyses, and correlation with the SF-36 and NRS pain score. Test-retest reliability was assessed in a subgroup of patients between 12 weeks after treatment and the retest 4 to 9 days later.

Results: A total of 238 patients were enrolled at 9 centers across North America; 153 of these patients had HRQOL data available at 12 weeks after treatment. Multitrait scaling analyses and confirmatory factor analyses resulted in a refined version of the SOSGOQ with 4 domains and 4 single items. The revised SOSGOQ (SOSGOQ2.0) demonstrated strong correlations with SF-36 and the ability to discriminate between clinically distinct patient groups. Reliability of the SOSGOQ2.0 was demonstrated to be good, with an intraclass correlation coefficient ranging from 0.58 to 0.92 for the different domains.

Conclusions: The SOSGOQ2.0 is a reliable and valid measure with which to evaluate HRQOL in patients with spinal metastases. It is recommended to use the SOSGOQ2.0 together with a generic HRQOL outcome measure to comprehensively assess HRQOL and increase sensitivity and specificity. Cancer 2018;124:1828-38. © 2018 The Authors. Cancer published by Wiley Periodicals, Inc. on behalf of American Cancer Society. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

Keywords: metastases; patient-reported outcomes; quality of life; reliability; spine; validity.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Patient selection flow diagram. SOSGOQ indicates Spine Oncology Study Group Outcomes Questionnaire.
Figure 2
Figure 2
Revised structure of the Spine Oncology Study Group Outcomes Questionnaire (SOSGOQ). (From AOSpine International, Used under CC BY‐NC‐ND 4.0).
See this image and copyright information in PMC

References

    1. Quaresma M, Coleman MP, Rachet B. 40‐year trends in an index of survival for all cancers combined and survival adjusted for age and sex for each cancer in England and Wales, 1971‐2011: a population‐based study. Lancet. 2015;385:1206‐1218. - PubMed
    1. Chow E, Nguyen J, Zhang L, et al; European Organization for Research Treatment of Cancer Quality of Life Group . International field testing of the reliability and validity of the EORTC QLQ‐BM22 module to assess health‐related quality of life in patients with bone metastases. Cancer. 2012;118:1457‐1465. - PubMed
    1. Street J, Lenehan B, Berven S, Fisher C. Introducing a new health‐related quality of life outcome tool for metastatic disease of the spine: content validation using the International Classification of Functioning, Disability, and Health; on behalf of the Spine Oncology Study Group. Spine (Phila Pa 1976). 2010;35:1377‐1386. - PubMed
    1. Ware JE, Kosinski M. The SF‐36 Health Survey (Version 2.0) Technical Note. Boston, MA: Health Assessment Laboratory; 1996.
    1. McHorney CA, Ware JE Jr, Lu JF, Sherbourne CD. The MOS 36‐Item Short‐Form Health Survey (SF‐36): III. Tests of data quality, scaling assumptions and reliability across diverse patient groups. Med Care. 1994;32:40‐66. - PubMed

MeSH terms

LinkOut - more resources