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. 1986 Feb;29(2):337-8.
doi: 10.1128/AAC.29.2.337.

Effect of ciprofloxacin on mitogen-stimulated lymphocyte proliferation

S V Gollapudi, R H Prabhala, H Thadepalli

Effect of ciprofloxacin on mitogen-stimulated lymphocyte proliferation

S V Gollapudi et al. Antimicrob Agents Chemother. 1986 Feb.

Abstract

Ciprofloxacin was tested for its inhibitory or stimulatory effects on concanavalin A- and phytohemagglutinin-stimulated proliferation (measured by [3H]thymidine uptake) of human peripheral blood mononuclear cells and murine splenocytes. Ciprofloxacin did not diminish or enhance mononuclear cell proliferation at concentrations of 5 to 125 micrograms/ml. Further, the proliferative response of splenocytes of mice previously treated with ciprofloxacin (40 mg/kg, twice daily for 5 days) was essentially similar to that of untreated controls.

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