Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1986 May;53(5):629-36.
doi: 10.1038/bjc.1986.106.

The use of an LH-RH agonist (ICI 118630, Zoladex) in advanced premenopausal breast cancer

M R Williams, K J Walker, A Turkes, R W Blamey, R I Nicholson
Free PMC article

The use of an LH-RH agonist (ICI 118630, Zoladex) in advanced premenopausal breast cancer

M R Williams et al. Br J Cancer. 1986 May.
Free PMC article

Abstract

Fifty-three premenopausal patients presenting with advanced breast cancer have been treated with a potent new luteinising hormone-releasing hormone agonist Zoladex (ICI 118630) in a phase I clinical trial. On progression of disease 26 patients have undergone therapeutic oophorectomy. We present the clinical and endocrinological responses to treatment in 45 assessable patients. The response rate to Zoladex in this series was 31% and the ER status of the primary tumour was predictive of a response to the luteinising hormone-releasing hormone.

PubMed Disclaimer

References

    1. Br J Cancer. 1979 Mar;39(3):274-9 - PubMed
    1. Yale J Biol Med. 1982 Jan-Feb;55(1):27-47 - PubMed
    1. Br J Cancer. 1979 Mar;39(3):268-73 - PubMed
    1. Surg Gynecol Obstet. 1964 Mar;118:524-40 - PubMed
    1. Cancer. 1977 Mar;39(3):1289-94 - PubMed

Publication types