Comment on

• Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain.

  Deng L, Wang C, Spencer E, Yang L, Braun A, You J, Slaughter C, Pickart C, Chen ZJ. Deng L, et al. Cell. 2000 Oct 13;103(2):351-61. doi: 10.1016/s0092-8674(00)00126-4. Cell. 2000. PMID: 11057907
• TAK1 is a ubiquitin-dependent kinase of MKK and IKK.

  Wang C, Deng L, Hong M, Akkaraju GR, Inoue J, Chen ZJ. Wang C, et al. Nature. 2001 Jul 19;412(6844):346-51. doi: 10.1038/35085597. Nature. 2001. PMID: 11460167