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. 1986;22(2):95-9.
doi: 10.1007/BF00199121.

Autologous responses to human leukaemic cells in mixed leucocyte culture

L K Ashman, D E O'Keefe, C A Juttner, I R Toogood, M S Rice

Autologous responses to human leukaemic cells in mixed leucocyte culture

L K Ashman et al. Cancer Immunol Immunother. 1986.

Abstract

Cryopreserved leukaemic blasts and remission non-T cells from 22 patients with acute leukaemia (15 lymphocytic, 7 non-lymphocytic) were tested as stimulators of autologous remission T cells and normal allogeneic T cells in primary and secondary MLC. In most cases the autologous response elicited by leukaemic cells was less than or equal to that elicited by remission non-T cells. However, T cells from 2 patients in long-standing first remission from ANLL displayed greater proliferation in response to leukaemic blasts than to remission non-T cells in both primary and secondary MLC. The results are suggestive of sensitization of these 2 patients to leukaemia-specific antigens, but other possible explanations are discussed.

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