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. 2017 Dec;61(6):600-607.
doi: 10.1590/2359-3997000000309.

Serum selenium and selenoprotein-P levels in autoimmune thyroid diseases patients in a select center: a transversal study

Marco Aurélio Ferreira Federige  1 , João Hamilton Romaldini  1 , Ana Beatriz Pinotti Pedro Miklos  1 , Marcia Kiyomi Koike  1 , Kioko Takei  1 , Evandro de Souza Portes  1
Affiliations

Serum selenium and selenoprotein-P levels in autoimmune thyroid diseases patients in a select center: a transversal study

Marco Aurélio Ferreira Federige et al. Arch Endocrinol Metab. 2017 Dec.

Abstract

Objective: Selenium (Se) supplementation has been used to help prevent the progression of Graves' ophthalmopathy (GO) and autoimmune thyroid diseases (AITD) patients. We investigated Se serum and selenoprotein P (SePP) levels in Graves' disease (GD) with and without GO, Hashimoto's thyroiditis (HT) patients and in 27 control individuals (C).

Subjects and methods: We studied 54 female and 19 male patients: 19 with GD without GO, 21 GD with GO, 14 with HT and 19 with HT+LT4. Se values were measured using graphite furnace atomic absorption spectrophotometry. Serum SePP levels were measured by ELISA.

Results: Median Se levels were similar among all groups; GD patients: 54.2 (46.5-61.1 μg/L), GO: 53.6 (43.5-60.0 μg/L), HT: 51.9 (44.6-58.5 μg/L), HT+LT4 54.4 (44-63.4) and C group patients: 56.0 (52.4-61.5 μg/L); P = 0.48. However, serum SePP was lower in GO patients: 0.30 (0.15-1.05 μg/mL) and in HT patients: 0.35 (0.2-1.17 μg/mL) compared to C group patients: 1.00 (0.564.21 μg/mL) as well as to GD patients: 1.19 (0.62-2.5 μg/mL) and HT+LT4 patients: 0.7 (0,25-1.95); P = 0.002. Linear regression analysis showed a significant relationship between SePP and TPOAb values (r = 0.445, R2 = 0.293; P < 0.0001). Multiple regression analysis found no independent variables related to Se or SePP.

Conclusion: A serum Se concentration was lower than in some other countries, but not significantly among AITD patients. The low serum SePP levels in GO and HT patients seems to express inflammatory reactions with a subsequent increase in Se-dependent protein consumption remains unclear.

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Conflict of interest statement

Disclosure: no potential conflict of interest relevant to this article was reported.

Figures

Figure 1
Figure 1. Individual serum selenium (Se) concentrations expressed as median and interquartile ranges. Control individuals (C), Hashimoto's thyroiditis (HT), Graves'disease (GD), Graves’ Ophthalmopathy (GO) and Hashimoto's thyroiditis levothyroxine (HT + LT4) patients.
P value = 0.48; Kruskal-Wallis test.
Figure 2
Figure 2. Individual serum selenoprotein P (SePP) concentrations expressed as median and interquartile ranges. Control individuals (C), Hashimoto's thyroiditis (HT), Graves’ disease (GD), Graves’ Ophthalmopathy (GO) and Hashimoto's thyroiditis levothyroxine (HT + LT4) patients.
Figure 3
Figure 3. Linear regression analysis between Selenoprotein P (SePP) and thyroid peroxidase antibody (TPOAb): r = 0.445, r2 = 0.293, p < 0.0001, n = 73.
None
None
See this image and copyright information in PMC

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