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Review
. 2018 Jan 24:13:51-70.
doi: 10.1146/annurev-pathol-020117-044030.

Desmosomes in Human Disease

Nicole A Najor  1
Affiliations
Review

Desmosomes in Human Disease

Nicole A Najor. Annu Rev Pathol. .

Abstract

Tissue integrity is crucial for maintaining the homeostasis of living organisms. Abnormalities that affect sites of cell-cell contact can cause a variety of debilitating disorders. The desmosome is an essential cell-cell junctional protein complex in tissues that undergo stress, and it orchestrates intracellular signal transduction. Desmosome assembly and junctional integrity are required to maintain the overall homeostasis of a tissue, organ, and organism. This review discusses the desmosome and the human diseases associated with its disruption.

Keywords: armadillo proteins; desmosomal cadherins; desmosomal diseases; plakin proteins.

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