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Review
. 2018 Feb 6;10(2):64.
doi: 10.3390/v10020064.

The Magistral Phage

Jean-Paul Pirnay  1 , Gilbert Verbeken  2 , Pieter-Jan Ceyssens  3 , Isabelle Huys  4 , Daniel De Vos  5 , Charlotte Ameloot  6 , Alan Fauconnier  7   8
Affiliations
Review

The Magistral Phage

Jean-Paul Pirnay et al. Viruses. .

Abstract

Since time immemorial, phages-the viral parasites of bacteria-have been protecting Earth's biosphere against bacterial overgrowth. Today, phages could help address the antibiotic resistance crisis that affects all of society. The greatest hurdle to the introduction of phage therapy in Western medicine is the lack of an appropriate legal and regulatory framework. Belgium is now implementing a pragmatic phage therapy framework that centers on the magistral preparation (compounding pharmacy in the US) of tailor-made phage medicines.

Keywords: antibiotic; antimicrobial resistance; compounding pharmacy; magistral preparation; personalized medicine; phage therapy; regulatory framework.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
General flowchart of the magistral phage medicine process.
See this image and copyright information in PMC

References

    1. Tackling Drug-Resistant Infections Globally: Final Report and Recommendations. The Review on Antimicrobial Resistance. 2016 Release. [(accessed on 4 February 2018)]; Available online: https://amr-review.org/sites/default/files/160525_Final%20paper_with%20c....
    1. United Nations Draft Political Declaration of the High-Level Meeting of the General Assembly on Antimicrobial Resistance (16-16108 (E)). 2016 Release. [(accessed on 17 December 2017)]; Available online: http://www.un.org/pga/71/wp-content/uploads/sites/40/2016/09/DGACM_GAEAD....
    1. Thiel K. Old dogma, new tricks—21st Century phage therapy. Nat. Biotechnol. 2004;22:31–36. doi: 10.1038/nbt0104-31. - DOI - PubMed
    1. Hall A.R., De Vos D., Friman V.P., Pirnay J.P., Buckling A. Effects of sequential and simultaneous applications of bacteriophages on populations of Pseudomonas aeruginosa in vitro and in wax moth larvae. Appl. Environ. Microbiol. 2012;78:5646–5652. doi: 10.1128/AEM.00757-12. - DOI - PMC - PubMed
    1. Jennes S., Merabishvili M., Soentjens P., Pang K.W., Rose T., Keersebilck E., Soete O., François P.M., Teodorescu S., Verween G., et al. Use of bacteriophages in the treatment of colistin-only-sensitive Pseudomonas aeruginosa septicaemia in a patient with acute kidney injury—A case report. Crit. Care. 2017;21:129. doi: 10.1186/s13054-017-1709-y. - DOI - PMC - PubMed

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