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Review
. 2018 Feb 7;44(1):22.
doi: 10.1186/s13052-018-0461-5.

Thyroid function test evolution in children with Hashimoto's thyroiditis is closely conditioned by the biochemical picture at diagnosis

Giuseppe Crisafulli  1 , Romina Gallizzi  1 , Tommaso Aversa  1 , Giuseppina Salzano  1 , Mariella Valenzise  1 , Malgorzata Wasniewska  1 , Filippo De Luca  2 , Giuseppina Zirilli  1
Affiliations
Review

Thyroid function test evolution in children with Hashimoto's thyroiditis is closely conditioned by the biochemical picture at diagnosis

Giuseppe Crisafulli et al. Ital J Pediatr. .

Abstract

ᅟ: Aim of this commentary is to summarize the salient literature views on the relationships between presentation and evolution patterns of thyroid function in children with Hashimoto's thyroiditis (HT). According to the most recent reports, children with HT and subclinical hypothyroidism (SH) are more prone to the risk of developing severe thyroid dysfunctions over time, if compared to those presenting with euthyroidism. In contrast, children presenting with HT and either overt or subclinical hyperthyroidism are incline to exhibit a definitive resolution of the hyperthyroid phase within some months, although there is a wide variability between the different individuals. The natural history of frank hypothyroidism in the children with HT has never been investigated so far, since in these cases an immediate onset of replacement treatment is mandatory.

Conclusions: 1) a deterioration of thyroid status over time may be observed especially in the children presenting with SH, but also in those presenting with euthyroidism; 2) a definitive resolution of the hyperthyroid phase is generally observed in those presenting with either overt or subclinical hyperthyroidism.

Keywords: Hashitoxicosis; Overt hyperthyroidism; Overt hypothyroidism; Subclinical hyperthyroidism; Subclinical hypothyroidism; Thyroid status natural course.

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The authors declare that they have no competing interests.

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Figures

Fig. 1
Fig. 1
Prevalence (%) of the different biochemical pictures of thyroid function found, at the end of a 5-year follow-up, in two groups of children with Hashimoto’s thyroiditis, who had initially presented with either euthyroidism (Group A) or subclinical hypothyroidism SH (Group B) (according to the results of Reference 20 study)
Fig. 2
Fig. 2
Prevalence (%) of the main biochemical pictures of thyroid function found, at the end of a 5-year follow-up, in three groups of children with Hashimoto’s thyroiditis (HT)-related subclinical hypothyroidism (SH) and no chromosomopathies (Group A) or HT-related SH and Turner syndrome (Group B) or HT-related SH and Down’s syndrome (Group C) (according to the results of Reference 26 study)
See this image and copyright information in PMC

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