Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Oct-Dec;33(4):529-533.
doi: 10.4103/0970-9185.222523.

Evaluation of effect of entropy monitoring on isoflurane consumption and recovery from anesthesia

Kush Ashokkumar Goyal  1 , Anitha Nileshwar  1 , Lokvendra Singh Budania  1 , Yogesh Gaude  1 , Shaji Mathew  1 , Shriram Vaidya  1
Affiliations

Evaluation of effect of entropy monitoring on isoflurane consumption and recovery from anesthesia

Kush Ashokkumar Goyal et al. J Anaesthesiol Clin Pharmacol. 2017 Oct-Dec.

Abstract

Background and aims: Entropy monitoring entails measurement of the effect of anesthetic on its target organ rather than merely the concentration of anesthetic in the brain (indicated by alveolar concentration based on which minimum alveolar concentration [MAC] is displayed). We proposed this prospective randomised study to evaluate the effect of entropy monitoring on isoflurane consumption and anesthesia recovery period.

Material and methods: Sixty patients undergoing total abdominal hysterectomy under general anesthesia using an endotracheal tube were enrolled in either clinical practice (CP) or entropy (E) group. In group CP, isoflurane was titrated as per clinical parameters and MAC values, while in Group E, it was titrated to entropy values between 40 and 60. Data including demographics, vital parameters, alveolar isoflurane concentration, MAC values, entropy values, and recovery profile were recorded in both groups.

Results: Demographic data and duration of surgery were comparable. Time to eye opening on command and time to extubation (mean ± standard deviation) were significantly shorter, in Group E (6.6 ± 3.66 and 7.27 ± 4.059 min) as compared to Group CP (9.77 ± 5.88 and 11.63 ± 6.90 min), respectively. Mean isoflurane consumption (ml/h) was 10.81 ± 2.08 in Group E and 11.45 ± 2.24 in Group CP and was not significantly different between the groups. Time to readiness to recovery room discharge and postanesthesia recovery scores were also same in both groups.

Conclusion: Use of entropy monitoring does not change the amount of isoflurane consumed during maintenance of anesthesia or result in clinically significant faster recovery.

Keywords: Anesthesia recovery period; awareness; entropy; isoflurane.

PubMed Disclaimer

Conflict of interest statement

There are no conflicts of interest.

References

    1. Smajic J, Praso M, Hodzic M, Hodzic S, Srabovic-Okanovic A, Smajic N, et al. Assessment of depth of anesthesia: PRST score versus bispectral index. Med Arh. 2011;65:216–20. - PubMed
    1. Rani DD, Harsoor S. Depth of general anaesthesia monitors. Indian J Anaesth. 2012;56:437–41. - PMC - PubMed
    1. Drummond JC. Monitoring depth of anesthesia: With emphasis on the application of the bispectral index and the middle latency auditory evoked response to the prevention of recall. Anesthesiology. 2000;93:876–82. - PubMed
    1. Stoelting RK, Hillier SC, editors. Stoelting's Pharmacology and Physiology in Anaesthetic Practice. New York: Lippincott Williams & Wilkins; 2006. Pharmacokinetics and pharmacodynamics of injected and inhaled drugs; pp. 23–82.
    1. American Society of Anesthesiologists Task Force on Intraoperative Awareness. Practice advisory for intraoperative awareness and brain function monitoring: A report by the American Society of Anesthesiologists task force on intraoperative awareness. Anesthesiology. 2006;104:847–64. - PubMed