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. 2017 Dec 20;9(2):1553-1562.
doi: 10.18632/oncotarget.23458. eCollection 2018 Jan 5.

Associations of TAP1 genetic polymorphisms with atopic diseases: asthma, rhinitis and dermatitis

Rongzeng Liu #  1 , Xiafei Chen #  2 , Jingjiao Qi  1
Affiliations

Associations of TAP1 genetic polymorphisms with atopic diseases: asthma, rhinitis and dermatitis

Rongzeng Liu et al. Oncotarget. .

Abstract

Controversial findings have been reported regarding to the effect of the transporter associated with antigen processing 1 (TAP1) polymorphisms exerted on the atopic diseases susceptibility. To gain a better understanding of the effects of TAP1 polymorphisms on the risk of atopic diseases, a retrospective study was carried out to evaluate the association of the most common TAP1 polymorphisms, rs1057141 and rs1135216, with the risk of atopic diseases. From studies published in PubMed, Embase, and Web of Science up to July 2017, ten eligible studies were selected for meta-analysis. The pooled results from rs1135216 polymorphism showed increased risk of atopic diseases in homozygote and recessive comparison. From the subgroup analysis by ethnicity, it was found that rs1135216 polymorphism contributed to atopic diseases susceptibility among Africans in all the five genetic models. Subgroup analysis by atopic types indicated significant association of TAP1 polymorphism rs1135216 with asthma in the allele, dominant and recessive models and with allergic rhinitis in the recessive model. As to rs1057141, increased risk of atopic disease in the allelic, dominant and heterozygous model was found in African population. Overall, this meta-analysis study demonstrated that rs1135216 polymorphism may contribute to atopic diseases susceptibility in Asians and Africans as assessed in this study. However, well designed large-scale case-control studies are needed to confirm such preliminary findings.

Keywords: Immunology; TAP1; allergic rhinitis; atopic dermatitis; atopic diseases; polymorphism.

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Conflict of interest statement

CONFLICTS OF INTEREST All authors declare no conflicts of interest.

Figures

Figure 1
Figure 1. Workflow for literature selection
Figure 2
Figure 2. Subgroup analysis of the relationship between TAP1 rs1057141 polymorphism and atopic diseases stratified by the ethnicity of study population
I2 and Pheterogeneity for the outcomes of the allelic comparison in Asians (I2=22.1%, Ph=0.260) and Africans (I2 = 0, Ph= 0.852).
Figure 3
Figure 3. Overall meta-analysis of the relationship between TAP1 rs1135216 polymorphism and atopic diseases risk
A. Recessive model (GG vs. AA+AG); B. Homozygote model (GG vs. AA).
Figure 4
Figure 4. Subgroup analysis of the relationship between TAP1 rs1135216 polymorphism and atopic diseases stratified by the ethnicity of study population
I2 and Pheterogeneity for the outcomes of the homozygous comparison in Asians (I2 = 0%, Ph=0.995) and Africans (I2=0%, Ph=0.532).
Figure 5
Figure 5. The impact of individual studies on the overall OR in allele model (G vs. A)
A. rs1057141; B. rs1135216.
See this image and copyright information in PMC

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