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. 2017 Dec 15;9(2):2770-2781.
doi: 10.18632/oncotarget.23449. eCollection 2018 Jan 5.

G protein beta 3(GNβ3) C825T polymorphism and irritable bowel syndrome susceptibility: an updated meta-analysis based on eleven case-control studies

Dongbo Jiang #  1 , Dong Huang #  1 , Weiming Cai  1   2 , Ting Li  1 , Yan Wang  1 , Huayan Chen  1 , Tangming Guan  1   2 , Xiaoli Ma  1   3
Affiliations

G protein beta 3(GNβ3) C825T polymorphism and irritable bowel syndrome susceptibility: an updated meta-analysis based on eleven case-control studies

Dongbo Jiang et al. Oncotarget. .

Abstract

Several studies have reported an association between GNβ3 C825T polymorphism and irritable bowel syndrome (IBS). However, the results remain inconclusive and controversial, particularly for the data derived from different ethnicities and IBS subtypes. Therefore, we performed an updated meta-analysis to evaluate this association. All eligible case-control studies that met the search criteria were retrieved from multiple databases, and eleven case-control studies were included for detailed evaluation. The pooled odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated to assess the strengths of the association between GNβ3 C825T polymorphism and susceptibility to IBS and its subtypes. Our meta-analysis found no significantly associations of GNβ3 C825T polymorphism with IBS risk in all populations. Whereas the C allele was demonstrated to be a decreased risk factor for constipation predominant IBS (IBS-C) in allele model. Additionally, the CC genotype was found to be associated with increased diarrhea predominant IBS (IBS-D) risk in recessive model. Subgroup analysis by ethnicity revealed that these associations held true for the Asian subpopulation. In conclusion, this meta-analysis suggests the C allele of GNβ3 C825T might be associated with a decreased risk of IBS-C, and the CC genotype of GNβ3 might be associated with increased IBS-D risk.

Keywords: GNβ3; case-control; irritable bowel syndrome; meta-analysis; polymorphism.

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Conflict of interest statement

CONFLICTS OF INTEREST The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1. Flow diagram of selection of eligible studies
Figure 2
Figure 2. The associations of GNβ3 C825T with IBS in different genetic models
(A) Allele model (C vs. T). (B) Codominant model (CC vs. TT). (C) Codominant model (CT vs. TT). (D) Dominant model (CC + CT vs. TT). (E) Recessive model (CC vs. TT + CT).
Figure 3
Figure 3. The associations of GNβ3 C825T with IBS-C in different genetic models
(A) Allele model (C vs. T). (B) Codominant model (CC vs. TT). (C) Codominant model (CT vs. TT). (D) Dominant model (CC + CT vs. TT). (E) Recessive model (CC vs. TT + CT).
Figure 4
Figure 4. The associations of GNβ3 C825T with IBS-D in different genetic models
(A) Allele model (C vs. T). (B) Codominant model (CC vs. TT). (C) Codominant model (CT vs. TT). (D) Dominant model (CC + CT vs. TT). (E) Recessive model (CC vs. TT + CT).
Figure 5
Figure 5. Sensitivity analysis of the association of GNβ3 C825T and IBS in the different genetic models
(A) Allele model (C vs. T). (B) Codominant model (CC vs. TT). (C) Codominant model (CT vs. TT). (D) Dominant model (CC + CT vs. TT). (E) Recessive model (CC vs. TT + CT).
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