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Review
. 2017 Dec 8;9(2):2912-2922.
doi: 10.18632/oncotarget.23131. eCollection 2018 Jan 5.

The dawn of the liquid biopsy in the fight against cancer

Irma G Domínguez-Vigil  1 , Ana K Moreno-Martínez  1   2 , Julia Y Wang  3 , Michael H A Roehrl  4 , Hugo A Barrera-Saldaña  1   5
Affiliations
Review

The dawn of the liquid biopsy in the fight against cancer

Irma G Domínguez-Vigil et al. Oncotarget. .

Abstract

Cancer is a molecular disease associated with alterations in the genome, which, thanks to the highly improved sensitivity of mutation detection techniques, can be identified in cell-free DNA (cfDNA) circulating in blood, a method also called liquid biopsy. This is a non-invasive alternative to surgical biopsy and has the potential of revealing the molecular signature of tumors to aid in the individualization of treatments. In this review, we focus on cfDNA analysis, its advantages, and clinical applications employing genomic tools (NGS and dPCR) particularly in the field of oncology, and highlight its valuable contributions to early detection, prognosis, and prediction of treatment response.

Keywords: cfDNA; ctDNA; diagnostics; early detection; liquid biopsy.

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Conflict of interest statement

CONFLICT OF INTEREST The authors have no disclosures.

Figures

Figure 1
Figure 1. Timeline of liquid biopsy development
Figure 2
Figure 2. Number of publications per year in PubMed, using the terms “liquid biopsy”, “cell free DNA”, “circulating tumor DNA”, “exosomes”, “micro RNA”, and “circulating tumor cells” as of July 1, 2017
Figure 3
Figure 3
Comparison of features between surgical (tissue-based) and liquid biopsies (left) and overview of the various elements of the liquid biopsy workflow (A-F, right).
See this image and copyright information in PMC

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