Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2018 May 4;14(5):1064-1068.
doi: 10.1080/21645515.2018.1438028. Epub 2018 Feb 26.

Cross-protection induced by VA-MENGOC-BC® vaccine

Rolando Felipe Ochoa-Azze  1
Affiliations
Comment

Cross-protection induced by VA-MENGOC-BC® vaccine

Rolando Felipe Ochoa-Azze. Hum Vaccin Immunother. .

Abstract

I would like to comment on the article "Commentary: Impact of meningococcal group B OMV vaccines, beyond their brief", DOI: 10.1080/21645515.2017.1381810. The author states that meningococcal group B OMVs vaccines -such as VA-MENGOC-BC®- may induce moderate protection against Neisseria gonorrhoeae. I agree. However, the author states that "there was no evidence of effectiveness in the younger children." The effectiveness of VA-MENGOC-BC® in heterologous contexts has been higher than 80% in individuals older than 4 years old, but the effectiveness in younger children should not be undervalued; it has usually been higher than 60%, and results markedly higher when evaluated based on mortality rates. There is strong evidence that VA-MENGOC-BC® may induce cross-protection against heterologous N. meningitidis strains and N. gonorrhoeae.

Keywords: Neisseria gonorrhoeae; Neisseria meningitidis; gonorrhoea; meningococcal disease; vaccine.

PubMed Disclaimer

Comment in

Comment on

References

    1. Oviedo-Orta E, Ahmed S, Rappuoli R, Black S. Prevention and control of meningococcal outbreaks: The emerging role of serogroup B meningococcal vaccines. Vaccine 2015;33(31):3628–35. doi: 10.1016/j.vaccine.2015.06.046. PMID:26093201. - DOI - PubMed
    1. Bianchi A, Fantoni S, Prugnola A. Meningococcal B vaccine and the vision of a meningitis free world. J Prev Med Hyg. 2015;56(3):E140–3. PMID:26788735. - PMC - PubMed
    1. Sotolongo F, Campa C, Casanueva V, Fajardo E, Cuevas I, González N. Cuban meningococcal BC vaccine: experiences & contributions from 20 years of application. MEDICC Rev. 2007;9(1):16–22. PMID:21487356. - PubMed
    1. Ochoa RF, Sierra G. Vacunas contra la enfermedad meningocócica In: Ochoa RF, Menéndez J, editor(s), Prevención de la enfermedad meningocócica. 1st ed. La Habana, Cuba: Finlay Ediciones; 2010. pp. 67–84. (Spanish)..
    1. Galloway Y, Stehr-Green P, McNicholas A, O`Hallahan J. Use of an observational cohort study to estimate the effectiveness of the New Zealand group B meningococcal vaccines in children aged under 5 years. Int J Epidemiol. 2009;38(2):413–8. doi: 10.1093/ije/dyn228. PMID:18988650. - DOI - PubMed

Substances

LinkOut - more resources