KRAS^G12D Gene Dosage Drives Pancreatic Tumor Evolution and Progression

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Comment

No authors listed. Cancer Discov. 2018 Mar.

. 2018 Mar;8(3):265.

doi: 10.1158/2159-8290.CD-RW2018-020. Epub 2018 Feb 2.

Abstract

Allelic imbalance with increased Kras^G12D gene dosage drives key PDAC characteristics.

Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes.
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