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. 1986 Jan;29(1):40-3.
doi: 10.1128/AAC.29.1.40.

In vitro evaluation of A-56619 and A-56620, two new quinolones

A L Barry, C Thornsberry, R N Jones

In vitro evaluation of A-56619 and A-56620, two new quinolones

A L Barry et al. Antimicrob Agents Chemother. 1986 Jan.

Abstract

The in vitro activities of two new aryl-fluoroquinolones (A-56619 and A-56620) were compared with those of ciprofloxacin, ofloxacin, enoxacin, and norfloxacin. All six quinolones had broad spectra of antibacterial activity; the streptococci, Pseudomonas maltophilia, and Pseudomonas cepacia were the least susceptible. A-56619, A-56620, and chloramphenicol had similar activity against anaerobic bacteria. With both drugs, a low frequency of resistant variants (less than 10(-8)) was observed. By regression analysis, A-56619 MICs correlated best with ofloxacin MICs and A-56620 was most similar to ciprofloxacin.

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References

    1. Antimicrob Agents Chemother. 1980 Apr;17(4):757-61 - PubMed
    1. Antimicrob Agents Chemother. 1984 Jun;25(6):775-7 - PubMed
    1. Antimicrob Agents Chemother. 1983 Nov;24(5):754-63 - PubMed
    1. Antimicrob Agents Chemother. 1982 Oct;22(4):548-53 - PubMed