Alternative NAD(P)H dehydrogenase and alternative oxidase: Proposed physiological roles in animals

Abstract

The electron transport systems in mitochondria of many organisms contain alternative respiratory enzymes distinct from those of the canonical respiratory system depicted in textbooks. Two of these enzymes, the alternative NADH dehydrogenase and the alternative oxidase, were of interest to a limited circle of researchers until they were envisioned as gene therapy tools for mitochondrial disease treatment. Recently, these enzymes were discovered in several animals. Here, we analyse the functioning of alternative NADH dehydrogenases and oxidases in different organisms. We propose that both enzymes ensure bioenergetic and metabolic flexibility during environmental transitions or other conditions which may compromise the operation of the canonical respiratory system.

Keywords: Comparative bioenergetics; Cyanide-resistant respiration; Gene therapy; Hypoxia; Mitochondrial disease; Rotenone-insensitive NADH dehydrogenase.