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Review
. 2018 Oct 7;504(3):617-622.
doi: 10.1016/j.bbrc.2018.02.019. Epub 2018 Feb 5.

An update on oxysterol biochemistry: New discoveries in lipidomics

William J Griffiths  1 , Yuqin Wang  2
Affiliations
Review

An update on oxysterol biochemistry: New discoveries in lipidomics

William J Griffiths et al. Biochem Biophys Res Commun. .

Abstract

Oxysterols are oxidised derivatives of cholesterol or its precursors post lanosterol. They are intermediates in the biosynthesis of bile acids, steroid hormones and 1,25-dihydroxyvitamin D3. Although often considered as metabolic intermediates there is a growing body of evidence that many oxysterols are bioactive and their absence or excess may be part of the cause of a disease phenotype. Using global lipidomics approaches oxysterols are underrepresented encouraging the development of targeted approaches. In this article, we discuss recent discoveries important in oxysterol biochemistry and some of the targeted lipidomic approaches used to make these discoveries.

Keywords: Cancer; Cholesterol; Cytochrome P450; Hydroxysteroid dehydrogenase; Immunity; LC-MS; Sterol.

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Figures

Image 1
Graphical abstract
Fig. 1
Fig. 1
Schematic representation of the regulation of immune responses by 25-HC and 7α,25-diHC.
Fig. 2
Fig. 2
Schematic representation of the role of oxysterols in the Hh signalling pathway.
Fig. 3
Fig. 3
Schematic representation of the involvement of oxysterols in cancer.
See this image and copyright information in PMC

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