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Review
. 2018 Jan 15;10(1):1-12.
eCollection 2018.

Regulatory role of long non-coding RNAs during reproductive disease

Kangsheng Liu  1 , Xiaodong Mao  2 , Yajun Chen  3 , Taiping Li  4 , Hua Ton  5
Affiliations
Review

Regulatory role of long non-coding RNAs during reproductive disease

Kangsheng Liu et al. Am J Transl Res. .

Abstract

Long non-coding RNA (lncRNA) is a group of RNAs with broad biogenesis, which are longer than 200 nt and highly conserved in their secondary and tertiary structures. lncRNA that broadly participates in varied physiological processes in organisms has abundant biological function and can regulate expression of target genes at transcriptional, post-transcriptional and epigenetic levels. LncRNAs can also affect the development of diseases, and therefore be used to diagnose and treat diseases. With new sequencing and microarray techniques, hundreds of lncRNAs involved in reproductive disorders have been identified, but their functions in these disorders are undefined. In this paper, we reviewed the studies on how lncRNAs participate in the development of reproductive disorders, hoping our outcome can instruct the future study and provide new biomarkers and therapies for reproductive disorders.

Keywords: HongrES2; Hotair; LncRNA; Malat1; Mrh1; Neat1; Pcat1; Schlap1; cumulus cell; placentation; reproductive diseases.

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Conflict of interest statement

None.

Figures

Figure 1
Figure 1
Structural classification of lncRNAs. LncRNAs may be stand-alone transcription units, or they may be transcribed from enhancers, promoters, or introns of other genes; from pseudogenes; or antisense to other genes with varying degrees of overlap, from none, to partial, to complete. lncRNAs may also host one or more small RNAs within their transcription units (Image from [9]).
Figure 2
Figure 2
Classification of lncRNAs.
Figure 3
Figure 3
Different expression of lncRNA build up a regulatory system in reproductive diseases. NEAT1: Nclear paraspeckle assembly transcript 1; Mrh1: Miotic recombination hot spot locus; Mil-HongrES2: a1.6kb mRNA-like precursor that gives rise to a new microRNA-like small RNA; Neat AK124742: A newly detected lncRNA that was identified as being natural antisense to PSMD6 and involved in oocyte maturation and embryo development; LncRNA274: A specifically high expressed in ovary; Xist: X chromosome inactive-specific transcript; H19: Imprinted maternally expressed transcript; MALAT1: Metastasis-associated lung adenocarcinoma transcript 1; HOTAIR: HOX transcript antisense RNA; PCAT1: Prostate cancer-associated transcript 1; PCAT1: Prostate cancer-associated transcript 1; Schlap1: second chromosome locus associated with prostate-1.
See this image and copyright information in PMC

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